(R)-methyl 4-(2-(2-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-fluorophenylcarbamoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)picolinate

Base Information

Chemical Name:(R)-methyl 4-(2-(2-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-fluorophenylcarbamoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)picolinate
CAS No.:1350918-01-2
Molecular Formula:C₂₂H₂₃FN₆O₃
Molecular Weight:438.461
Hs Code.:

(R)-methyl 4-(2-(2-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-fluorophenylcarbamoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)picolinate

Synonyms:(R)-methyl 4-(2-(2-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-fluorophenylcarbamoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)picolinate

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Chemical Property of (R)-methyl 4-(2-(2-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-fluorophenylcarbamoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)picolinate

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Technology Process of (R)-methyl 4-(2-(2-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-fluorophenylcarbamoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)picolinate

There total 6 articles about (R)-methyl 4-(2-(2-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-fluorophenylcarbamoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: C₃₂H₄₂FN₇O₄Si

: 1350918-01-2
(R)-methyl 4-(2-(2-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-fluorophenylcarbamoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)picolinate

Guidance literature:: methanol; C₃₂H₄₂FN₇O₄Si; With hydrogenchloride; In 1,4-dioxane; at 50 ℃;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 6921-22-8
1,2-difluoro-3-nitrobenzene

: 1350918-01-2
(R)-methyl 4-(2-(2-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-fluorophenylcarbamoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)picolinate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 50 °C

4: disodium hydrogenphosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

5: hydrogenchloride / 1,4-dioxane / 50 °C

With 4-methyl-morpholine; hydrogenchloride; disodium hydrogenphosphate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 1350918-01-2
(R)-methyl 4-(2-(2-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-fluorophenylcarbamoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)picolinate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 50 °C

4: disodium hydrogenphosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

5: hydrogenchloride / 1,4-dioxane / 50 °C

With 4-methyl-morpholine; hydrogenchloride; disodium hydrogenphosphate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;