2-phenoxyisonicotinonitrile

Base Information

• Chemical Name: 2-phenoxyisonicotinonitrile
• CAS No.: 81249-44-7
• Molecular Formula: C₁₂H₈N₂O
• Molecular Weight: 196.208
• Mol file: 81249-44-7.mol

Synonyms:2-phenoxyisonicotinonitrile

Chemical Property of 2-phenoxyisonicotinonitrile

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Phenoxyisonicotinonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenoxyisonicotinonitrile

There total 1 articles about 2-phenoxyisonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloro-4-pyridinenitrile (33252-30-1) + phenol (108-95-2,27073-41-2) → 2-phenoxyisonicotinonitrile (81249-44-7)

Guidance literature:

phenol; With caesium carbonate; N,N-dimethylethylenediamine; at 20 ℃; for 0.5h;

2-chloro-4-pyridinenitrile; at 80 ℃; for 2h;

Reference yield: 91.0%

2-phenoxyisonicotinonitrile (81249-44-7) → (2-phenoxypyridin-4-yl)methanamine

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 2h; under 760.051 Torr;

DOI:10.1021/acs.jmedchem.7b00345

Reference yield: 43.3%

2-phenoxyisonicotinonitrile (81249-44-7) → 2-phenoxy-4-pyridinecarboxaldehyde (1030829-46-9)

Guidance literature:

With diisobutylaluminium hydride; In toluene; Cooling with ice;

upstream raw materials:

2-chloro-4-pyridinenitrile

phenol

Downstream raw materials:

2-phenoxy-4-pyridinecarboxaldehyde

Refernces

• 1、 Rowbottom, Martin W.,Bain, Gretchen,Calderon, Imelda,Lasof, Taylor,Lonergan, David,Lai, Andiliy,Huang, Fei,Darlington, Janice,Prodanovich, Patricia,Santini, Angelina M.,King, Christopher D.,Goulet, Lance,Shannon, Kristen E.,Ma, Gina L.,Nguyen, Katherine,MacKenna, Deidre A.,Evans, Jilly F.,Hutchinson, John H.. "Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)". . p. 4403 - 4423. Retrieved 2017/06/05.
• 2、 -. "NOVEL PHENYL-ISOXAZOL-3-OL DERIVATIVE". Page/Page column 46. . Retrieved 2009/09/26.