1030829-46-9

Basic information

• Product Name: 2-phenoxy-4-pyridinecarboxaldehyde
• Synonyms: 2-phenoxy-4-pyridinecarboxaldehyde
• CAS NO: 1030829-46-9
• Molecular Weight: 199.209
• Mol File: 1030829-46-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-phenoxy-4-pyridinecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenoxy-4-pyridinecarboxaldehyde(1030829-46-9)
• EPA Substance Registry System: 2-phenoxy-4-pyridinecarboxaldehyde(1030829-46-9)

Safety Data

• Hazardous Substances Data: 1030829-46-9(Hazardous Substances Data)

Upstream product

• 118289-17-1 2-bromopyridine-4-carboxaldehyde 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 108-95-2 phenol 
• 81249-44-7 2-phenoxyisonicotinonitrile 

Relevant articles and documents

Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors

Mycobacterium tuberculosis thymidylate kinase (MtTMPK) has emerged as an attractive target for rational drug design. We recently investigated new families of non-nucleoside MtTMPK inhibitors in an effort to diversify MtTMPK inhibitor chemical space. We here report a new series of MtTMPK inhibitors by combining the Topliss scheme with rational drug design approaches, fueled by two co-crystal structures of MtTMPK in complex with developed inhibitors. These efforts furnished the most potent MtTMPK inhibitors in our assay, with two analogues displaying low micromolar MIC values against H37Rv Mtb. Prepared inhibitors address new sub-sites in the MtTMPK nucleotide binding pocket, thereby offering new insights into its druggability. We studied the role of efflux pumps as well as the impact of cell wall permeabilizers for selected compounds to potentially provide an explanation for the lack of correlation between potent enzyme inhibition and whole-cell activity.

NOVEL PHENYL-ISOXAZOL-3-OL DERIVATIVE

The present invention relates to a compound represented by formula (I), which has a GPR120 agonist action and thus is useful for treatment of diabetes mellitus or hyperlipidemia, or a pharmaceutically acceptable salt thereof. In the formula, (AA) represents a phenyl or the like, which may be substituted with a lower alkoxy group or the like; (BB) represents a divalent group or the like, derived by removal of two hydrogen atoms from a benzene which may be substituted with a halogen atom or the like; X represents a spacer having a main chain composed of 1-8 carbon atoms wherein 1-3 carbon atoms in the main chain may be substituted with an oxygen atom or the like; and Y represents a hydrogen atom or the like.