3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethyl-5-morpholinothiophene-2-carboxamide

Base Information

• Chemical Name: 3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethyl-5-morpholinothiophene-2-carboxamide
• CAS No.: 1394374-05-0
• Molecular Formula: C₂₁H₂₈N₄O₅S₂
• Molecular Weight: 480.609

Synonyms:3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethyl-5-morpholinothiophene-2-carboxamide

Chemical Property of 3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethyl-5-morpholinothiophene-2-carboxamide

Chemical Property:

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Technology Process of 3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethyl-5-morpholinothiophene-2-carboxamide

There total 6 articles about 3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethyl-5-morpholinothiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-propanoylbenzene-1-sulfonamide (90610-45-0) → 3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethyl-5-morpholinothiophene-2-carboxamide (1394374-05-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: ethyl acetate; N,N-dimethyl-formamide / 4 h / 25 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

2.2: 0 - 25 °C / Inert atmosphere

2.3: 0 - 20 °C / Inert atmosphere

3.1: toluene / 25 - 120 °C

4.1: potassium carbonate / acetone / 25 - 60 °C

4.2: 0 °C / Reflux

5.1: sodium hydroxide; ethanol / 25 - 100 °C

6.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0 - 25 °C / Inert atmosphere

7.1: triethylamine / dichloromethane / 0 - 25 °C

With oxalyl dichloride; ethanol; potassium tert-butylate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

N,N-dimethyl-N'-((4-propionylphenyl)sulfonyl)formimidamide (1394373-83-1) → 3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethyl-5-morpholinothiophene-2-carboxamide (1394374-05-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

1.2: 0 - 25 °C / Inert atmosphere

1.3: 0 - 20 °C / Inert atmosphere

2.1: toluene / 25 - 120 °C

3.1: potassium carbonate / acetone / 25 - 60 °C

3.2: 0 °C / Reflux

4.1: sodium hydroxide; ethanol / 25 - 100 °C

5.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0 - 25 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 0 - 25 °C

With oxalyl dichloride; ethanol; potassium tert-butylate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetone; toluene;

Reference yield:

ethyl-3-(4-(N-((dimethylamino)methylene) sulfamoyl)phenyl)-4-methyl-5-morpholinothiophene-2-carboxylate (1394373-93-3) → 3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethyl-5-morpholinothiophene-2-carboxamide (1394374-05-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; ethanol / 25 - 100 °C

2: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0 - 25 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 - 25 °C

With oxalyl dichloride; ethanol; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane;

upstream raw materials:

N,N-dimethyl-N'-((4-propionylphenyl)sulfonyl)formimidamide

4-propanoylbenzene-1-sulfonamide

N'-((4-(2-(1,3-dithiatan-2-ylidene)propanoyl)phenyl)sulfonyl)-N,N-dimethylformimidamide

N,N-dimethyl-N'-((4-(2-methyl-3-morpholino-3-thioxopropanoyl)phenyl)sulfonyl)formimidamide

Downstream raw materials:

4-(4-methyl-5-morpholino-2-propionylthiophen-3-yl)benzenesulfonamide

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