(R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-ol

Base Information

Chemical Name:(R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-ol
CAS No.:881920-67-8
Molecular Formula:C₁₆H₃₂OSi
Molecular Weight:268.515
Hs Code.:

Synonyms:(R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-ol

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Chemical Property of (R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-ol

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Technology Process of (R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-ol

There total 5 articles about (R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 70737-22-3
((E)-2-iodoethenyl)(trimethyl)silane

: 80434-59-9,485843-44-5,796865-68-4
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde

: 881920-65-6
(S,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-ol

: 881920-67-8
(R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-ol

Guidance literature:: ((E)-2-iodoethenyl)(trimethyl)silane; With tert.-butyl lithium; In diethyl ether; hexane; at -78 - 20 ℃;

(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde; With trimethylaluminum; In diethyl ether; hexane; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jo800817p

Reference yield:

: 881920-89-4
(E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-one

: 881920-67-8
(R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-ol

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at -78 ℃; for 0.333333h;
DOI:10.1021/ol053061g

Reference yield:

: 881920-65-6
(S,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-ol

: 881920-67-8
(R,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-(trimethylsilyl)prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / N-methylmorpholine N-oxide; tetrapropylammonium perruthenate; molecular sieves 4 Angstroem / CH₂Cl₂ / 0.58 h / 20 °C

2: lithium triethylborohydride / tetrahydrofuran / 0.33 h / -78 °C

With tetrapropylammonium perruthennate; 4 A molecular sieve; lithium triethylborohydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol053061g