α-<(phenylmethyl)amino>-2-naphthalenacetonitrile

Base Information

• Chemical Name: α-<(phenylmethyl)amino>-2-naphthalenacetonitrile
• CAS No.: 69243-87-4
• Molecular Formula: C₁₉H₁₆N₂
• Molecular Weight: 272.349
• Mol file: 69243-87-4.mol

Synonyms:α-<(phenylmethyl)amino>-2-naphthalenacetonitrile

Chemical Property of α-<(phenylmethyl)amino>-2-naphthalenacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-<(phenylmethyl)amino>-2-naphthalenacetonitrile

There total 2 articles about α-<(phenylmethyl)amino>-2-naphthalenacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

hydrogen cyanide (74-90-8) + (E)-N-benzyl-1-(naphthalen-2-yl)methanimine (141120-50-5) → α-<(phenylmethyl)amino>-2-naphthalenacetonitrile (69243-87-4)

Guidance literature:

With Sc[(R)-BINOL]2Li; In toluene; at -20 ℃; for 1h;

DOI:10.1016/S0957-4166(01)00144-6

Reference yield: 45.0%

trimethylsilyl cyanide (7677-24-9) + (E)-N-benzyl-1-(naphthalen-2-yl)methanimine (141120-50-5) → α-<(phenylmethyl)amino>-2-naphthalenacetonitrile (69243-87-4)

Guidance literature:

With Sc[(R)-BINOL]2Li; In toluene; at -20 ℃; for 3h;

DOI:10.1016/S0957-4166(01)00144-6

Reference yield: 90.0%

methyl 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate (1242071-55-1) + α-<(phenylmethyl)amino>-2-naphthalenacetonitrile (69243-87-4) → methyl 2-({benzyl[cyano(naphthalen-2-yl)methyl]amino}methyl)acrylate (1404296-12-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In toluene; at 30 ℃; for 3h; regioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1002/ejoc.201200642

upstream raw materials:

hydrogen cyanide

(E)-N-benzyl-1-(naphthalen-2-yl)methanimine

trimethylsilyl cyanide

Downstream raw materials:

methyl 2-({benzyl[cyano(naphthalen-2-yl)methyl]amino}methyl)acrylate