4,4'-difluoro-2,2'-dinitrodiphenylamine

Base Information

• Chemical Name: 4,4'-difluoro-2,2'-dinitrodiphenylamine
• CAS No.: 106754-79-4
• Molecular Formula: C₁₂H₇F₂N₃O₄
• Molecular Weight: 295.202
• Mol file: 106754-79-4.mol

Synonyms:4,4'-difluoro-2,2'-dinitrodiphenylamine

Chemical Property of 4,4'-difluoro-2,2'-dinitrodiphenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4'-difluoro-2,2'-dinitrodiphenylamine

There total 4 articles about 4,4'-difluoro-2,2'-dinitrodiphenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-fluoro-2-nitrobenzonitrile (80517-21-1) → 4-fluoro-2-nitrobenzoic acid (394-01-4) + 4,4'-difluoro-2,2'-dinitrodiphenyl (316-00-7) + 4,4'-difluoro-2,2'-dinitrodiphenylamine (106754-79-4)

Guidance literature:

With sulfuric acid; acetic acid; for 8h; Heating;

Reference yield: 71.0%

bis-(4-fluoro-phenyl)-amine (330-91-6) → 4,4'-difluoro-2,2'-dinitrodiphenylamine (106754-79-4)

Guidance literature:

bis-(4-fluoro-phenyl)-amine; With nitric acid; acetic acid; for 0.166667h; Cooling with ice;

With isopentyl nitrite; for 0.116667h; regioselective reaction; Cooling with ice;

DOI:10.1021/ic401496w

Reference yield:

N-(4-fluoro-2-nitrophenyl)acetamide (448-39-5) → 4,4'-difluoro-2,2'-dinitrodiphenylamine (106754-79-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / sodium ethoxide / ethanol / 4 h / Heating

2: 1.) aq.hydrochloric acid, NaNO₂, 2.) CuCN / 1.) 0-3 deg C, 1 hr., 2.) 80-90 deg C

3: 3.5 g / 1.) aq.H₂SO₄, acetic acid, 2.) acetic acid, acetic anhydride / 8 h / 1.) reflux, 8 hrs., 2.) ferlux 15 min.,

With hydrogenchloride; sulfuric acid; sodium ethanolate; acetic anhydride; acetic acid; sodium nitrite; In ethanol;

upstream raw materials:

4-fluoro-2-nitrobenzonitrile

2-nitro-4-fluoroaniline

N-(4-fluoro-2-nitrophenyl)acetamide

bis-(4-fluoro-phenyl)-amine