448-39-5

Basic information

• Product Name: 4'-FLUORO-2'-NITROACETANILIDE
• Synonyms: N-(4-FLUORO-2-NITROPHENYL)ACETAMIDE;4'-FLUORO-2'-NITROACETANILIDE;4-FLUORO-2-NITROACETANILIDE;LABOTEST-BB LT00455473;4-Fluoro-2-nitroacetanilide,98%;4'-Fluoro-2'-nitroacetanilide 98%;4'-FLUORO-2'-NITROACETANILIDE, 99+%;2'-Nitro-4'-fluoroacetoanilide
• CAS NO: 448-39-5
• Molecular Formula: C₈H₇FN₂O₃
• Molecular Weight: 198.15
• EINECS: 71-73 °C(lit.)
• Product Categories: Anilines, Amides & Amines;Fluorine Compounds;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks;Protected Amines
• Mol File: 448-39-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 71-73 °C(lit.)
• Boiling Point: 383 °C at 760 mmHg
• Flash Point: 185.4 °C
• Appearance: Ochre to yellow/Crystalline Powder
• Density: 1.3918 (estimate)
• Vapor Pressure: 4.54E-06mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4'-FLUORO-2'-NITROACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-FLUORO-2'-NITROACETANILIDE(448-39-5)
• EPA Substance Registry System: 4'-FLUORO-2'-NITROACETANILIDE(448-39-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 448-39-5(Hazardous Substances Data)

Usage

Chemical Properties

ochre-yellow crystalline powder

Synthesis Reference(s)

The Journal of Organic Chemistry, 16, p. 1450, 1951 DOI: 10.1021/jo50003a017

InChI:InChI=1/C8H7FN2O3/c1-5(12)10-7-3-2-6(9)4-8(7)11(13)14/h2-4H,1H3,(H,10,12)

Upstream product

• 351-83-7 4'-fluoroacetanilide 
• 591-09-3 nitro acetate 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 371-40-4 4-fluoroaniline 
• 625-58-1 ethyl nitrate 

Downstream Products

• 674284-49-2 1-(4-fluoro-2-nitrophenyl)-1H-pyrrole 
• 896429-57-5 5-fluoro-2-(1H-pyrrol-1-yl)aniline 
• 74916-51-1 3-amino-7-fluoro-1,2,4-benzotriazine-1-oxide 
• 1383844-79-8 3-(cyclohexylamino)-7-fluorobenzo[e][1,2,4]triazine-1,4-dioxide 
• 1357375-42-8 C₂₃H₂₁FN₄O₄ 
• 1357376-42-1 N-(4-fluoro-1H-indol-7-yl)acetamide 
• 446-09-3 2-bromo-5-fluoronitrobenzene 
• 575-21-3 N-(6-fluoro-[8]quinolyl)-anthranilic acid 
• 343-26-0 6-fluoro-8-nitroquinoline 
• 343-54-4 8-amino-6-fluoroquinoline 
• 583-42-6 5-fluoro-1,3-dihydro-2H-benzoimidazole-2-thione 
• 106754-79-4 4,4'-difluoro-2,2'-dinitrodiphenylamine 
• 106754-80-7 4-fluoro-2-nitrobenzamide 
• 80517-21-1 4-fluoro-2-nitrobenzonitrile 

Relevant articles and documents

Method for preparing 2-bromo-5-fluoroaniline

The invention discloses a method for preparing 2-bromo-5-fluoroaniline, belonging to the field of organic chemical synthesis. The preparation method comprises the following steps: with 4-fluoroanilineas a raw material, reacting 4-fluoroaniline with acetic anhydride to generate 4-fluoroacetanilide; performing nitrification; replacing acetamido groups with bromine; and reducing nitro groups. Thus,the 2-bromo-5-fluoroaniline with high yield and high purity is prepared. The method has the advantages of high product yield, high purity, easy availability of raw materials and simple operation, andis beneficial to industrial production.

Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: Definition of the structural determinants for enzyme inhibition

This paper describes the development of piperazine and 4-aminopiperidine carboxamides/carbamates supported on a pharmacogenic pyrroloquinoxaline scaffold as inhibitors of the endocannabinoid catabolizing enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Structure-activity relationships and molecular modelling studies allowed the definition of the structural requirements for dual FAAH/MAGL inhibition and led to the identification of a small set of derivatives (compounds 5e, i, k, m) displaying a balanced inhibitory profile against both enzymes, with compound 5m being the frontrunner of the subset. Favorable calculated physico-chemical properties suggest further investigation for specific analogues.

Mild, efficient and selective nitration of anilides, non-activated and moderately activated aromatic compounds with ammonium molybdate and nitric acid as a new nitrating agent

Ammonium molybdate [Mo(VI)] is operationally simple, environmentally safe and inexpensive reagent. Regioselective nitration of anilides, non-activated and moderately activated aromatic compounds could be afforded by employing ammonium molybdate and nitric acid as mild and effective nitrating agent. This procedure works efficiently under reflux conditions to prepare mononitroderivatives of anilides, non-activated and moderately activated aromatic compounds in good to excellent yield with high regioselectivity.