394-01-4

Usage

Uses

Used in Chemical Research:
4-Fluoro-2-nitrobenzoic acid is used as a chemical intermediate for studying the reactions of substituted pyridines with the salicyl phosphate dianion. This application is valuable for understanding the reactivity and properties of pyridine derivatives and their interactions with other chemical species.

Biochem/physiol Actions

4-Fluoro-2-nitrobenzoic acid enhances the binding of insulin to adipocytes.

InChI:InChI=1/C7H4FNO4/c8-4-1-2-5(7(10)11)6(3-4)9(12)13/h1-3H,(H,10,11)

Upstream product

• 446-10-6 2-nitro-4-fluorotoluene 
• 80517-21-1 4-fluoro-2-nitrobenzonitrile 
• 106754-80-7 4-fluoro-2-nitrobenzamide 
• 2923-96-8 4-fluoro-2-nitrobenzaldehyde 
• 390-06-7 4-fluoro-2-nitro-1,1′-biphenyl 
• 64-19-7 acetic acid 
• 364-78-3 2-nitro-4-fluoroaniline 
• 448-39-5 N-(4-fluoro-2-nitrophenyl)acetamide 
• 119-32-4 4-Methyl-3-nitroanilin 
• 731-86-2 4-Fluor-2-nitro-1-diacetoxymethyl-benzol 
• 459-56-3 4-fluorobenzylic alcohol 
• 1043416-40-5 (4-fluoro-2-nitrophenyl)methanol 

Downstream Products

• 446-32-2 4-fluoroanthranilic acid 
• 57750-82-0 4-Fluoro-2-nitrobenzoic acid chloride 
• 1546-96-9 5-Fluor-benzoldiazonium-2-carboxylat 
• 151504-81-3 methyl 4-fluoro-2-nitrobenzoate 
• 851847-21-7 N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-4-fluoro-2-nitrobenzamide 
• 865627-03-8 N-(1-benzyl-4-piperidyl)-4-fluoro-2-nitrobenzamide 
• 280771-80-4 N-(5-Chloropyridin-2-yl)-2-nitro-4-fluorobenzamide 
• 80517-22-2 2-amino-4-fluorobenzonitrile 
• 942271-60-5 tert-butyl 4-fluoro-2-nitrobenzoate 
• 120276-20-2 4-butoxy-2-nitrobenzoic acid 
• 1064657-16-4 1-benzyl-7-fluoro-3-phenyl-3,4-dihydro-1H-2,1-benzothiazin-4-one 2,2-dioxide 
• 1139573-80-0 2-(methyloxy)ethyl 4-fluoro-2-nitrobenzoate 
• 1175134-33-4 N-methoxy-N-methyl-4-fluoro-2-nitro-benzamide 
• 1393456-10-4 C₁₅H₁₀FNO₂S 

Relevant academic research and scientific papers

Preparation method of 2-amino-4-fluorobenzoic acid

The invention relates to a preparation method of 2-amino-4-fluorobenzoic acid, which comprises the following steps: by taking cheap and easily available 4-fluorobenzyl alcohol as a raw material, firstly carrying out nitration reaction to obtain a nitro substitute, then carrying out oxidation reaction on the nitro substitute to obtain benzoic acid oxide, and finally carrying out reduction reaction on the benzoic acid oxide to finally obtain 2-amino-4-fluorobenzoic acid which is high in purity and high in yield. The preparation method disclosed by the invention has the characteristics of cheap and easily available raw materials, short reaction route, conventional reaction, mild reaction conditions, high yield and easiness in industrial production.

3H-QUINAZOLIN-4-ONE DERIVATIVES

This invention relates to 3H-quinazolin-4-one derivatives as defined in the specification and claims, to a process for their preparation, to pharmaceutical compositions comprising them and to their use as selective monoamine oxidase B inhibitors.

Condensed pyrazole derivatives, process for producing the same and use thereof

Novel pharmaceutical compositions for inhibiting Th2-selective immune response and pharmaceutical compositions for inhibiting cyclooxygenase comprising condensed pyrazole derivatives represented by the general formula (I): or salts thereof.

AROMATIC AMIDES

This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

FLUORINATED TRICYCLIC NEUROLEPTICS WITH PROLONGED ACTION: 7-FLUORO-11--2-ISOPROPYL-10,11-DIHYDRODIBENZOTHIEPIN

Substitution reaction of 11-chloro-7-fluoro-2-isopropyl-10,11-dihydrodibenzothiepin with 1-(2-hydroxyethyl)piperazine gave the title compound I which proved a very potent and long acting oral neuroleptic agent ("isofloxythepin").Its resolution by means of dibenzoyl-(+)- and (-)-tartaric acid led to (-)- and (+)-enantiomer out of which the former represents the neuroleptically active component.In the synthetic sequence leading to I, preparation of two key intermediates was re-elaborated using new partial sequences: 4-fluoro-2-iodobenzoic acid (XIII) from 4-fluoro-2-nitroaniline (V) via the nitrile VI and the acids VIII and XII, and acetic acid (XVIII) from XIII via XIV and the compounds XV-XVII.The sulfoxides and N-oxides XIX-XXII were prepared as potential metabolites of isofloxithepin (I).