N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-succinamide

Base Information

Chemical Name:N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-succinamide
CAS No.:188728-69-0
Molecular Formula:C₂₄H₃₇N₃O₄
Molecular Weight:431.575
Hs Code.:

<i>N</i><sup>4</sup>-benzyloxy-<i>N</i><sup>1</sup>-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-succinamide

Synonyms:N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-succinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-succinamide

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Technology Process of N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-succinamide

There total 2 articles about N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.6%

: 4--2(R)-isobutylsuccinic acid

: 188728-68-9
L-cyclohexylglycine-N-methylamide

: 188728-69-0
N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-succinamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm970404a

Reference yield:

: 129213-83-8
(S)-2-amino-N-methyl-2-phenylacetamide

: 188728-69-0
N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-succinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) rhodium chloride trihydrate, 2.) NaBH₄ / 1.) EtOH, 30 deg C, 2 h, 2.) EtOH, RT, 4 h

2: 64.6 percent / 1-ethyl-3<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / Ambient temperature

With sodium tetrahydroborate; rhodium(III) chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm970404a