3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate

Base Information

Chemical Name:3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate
CAS No.:1281969-56-9
Molecular Formula:C₂H₃O₂*C₃₀H₃₀F₃N₆O₂
Molecular Weight:622.647
Hs Code.:

3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate

Synonyms:3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate

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Chemical Property of 3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate

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Technology Process of 3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate

There total 11 articles about 3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1281969-54-7
3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium bromide

: 631-61-8,92206-38-7
ammonium acetate

: 1281969-56-9
3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate

Guidance literature:: In acetonitrile;

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1281969-56-9
3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / Isopropyl acetate / -10 - 10 °C

2.1: sodium methylate / ethanol; methanol / 50 - 55 °C

3.1: nitric acid; iodine; sulfuric acid / acetic acid / -55 - 50 °C

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.17 h / 25 °C

4.2: 1 h / 25 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide; water / 12 h / 40 °C / Inert atmosphere

6.1: acetonitrile / -78 - 70 °C / 750.08 Torr / Sealed; Cooling with ethanol-dry ice

7.1: acetonitrile

With sulfuric acid; iodine; nitric acid; sodium methylate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In methanol; ethanol; Isopropyl acetate; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 694479-56-6
6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxylic acid

: 1281969-56-9
3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid; iodine; sulfuric acid / acetic acid / -55 - 50 °C

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.17 h / 25 °C

2.2: 1 h / 25 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide; water / 12 h / 40 °C / Inert atmosphere

4.1: acetonitrile / -78 - 70 °C / 750.08 Torr / Sealed; Cooling with ethanol-dry ice

5.1: acetonitrile

With sulfuric acid; iodine; nitric acid; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In water; acetic acid; N,N-dimethyl-formamide; acetonitrile;