(2-Methoxy-5-(pyridin-4-yl)phenyl)boronic acid

Base Information

• Chemical Name: (2-Methoxy-5-(pyridin-4-yl)phenyl)boronic acid
• CAS No.: 196861-33-3
• Molecular Formula: C₁₂H₁₂BNO₃
• Molecular Weight: 229.043
• European Community (EC) Number: 829-192-1
• DSSTox Substance ID: DTXSID70594224
• Wikidata: Q82489005
• Mol file: 196861-33-3.mol

Synonyms:196861-33-3;(2-Methoxy-5-(pyridin-4-yl)phenyl)boronic acid;2-Methoxy-5-(pyridin-4-yl)phenylboronic acid;2-METHOXY-5-(PYRIDINE-4-YL)PHENYLBORONIC ACID;(2-methoxy-5-pyridin-4-ylphenyl)boronic acid;[2-methoxy-5-(pyridin-4-yl)phenyl]boronic acid;5-PYRIDIN-4-YL-2-METHOXY-PHENYLBORONIC ACID;MFCD06658467;2-Methoxy-5-(pyridine-4-yl)phenylboronicacid;SCHEMBL7603732;DTXSID70594224;QLNYKODXAPVKKX-UHFFFAOYSA-N;AKOS015910212;AB25808;AS-44416;SY185543;2-Methoxy-5-(4-pyridyl)phenylboronic Acid;DB-044941;2-methoxy-5-(pyridin4-yl)phenylboronic acid;CS-0176142;[2-methoxy-5-(4-pyridyl)phenyl]boronic acid;EN300-76353;A813873;J-509820;Z1160866517;2-methoxy-5-(pyridine-4-yl)phenylboronic acid, AldrichCPR

Chemical Property of (2-Methoxy-5-(pyridin-4-yl)phenyl)boronic acid

Chemical Property:

• Vapor Pressure: 2.38E-09mmHg at 25°C
• Boiling Point: 462.4 °C at 760 mmHg
• Flash Point: 233.5 °C
• PSA: 62.58000
• Density: 1.25 g/cm³
• LogP: 0.43700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 229.0910234
• Heavy Atom Count: 17
• Complexity: 234

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-5-(pyridin-4-yl)phenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=C(C=CC(=C1)C2=CC=NC=C2)OC)(O)O

Technology Process of (2-Methoxy-5-(pyridin-4-yl)phenyl)boronic acid

There total 6 articles about (2-Methoxy-5-(pyridin-4-yl)phenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

triethyl borate (150-46-9) + 4-(3-bromo-4-methoxyphenyl)pyridine (191602-60-5) → 2-methoxy-5-(4-pyridinyl)phenylboronic acid (196861-33-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -85 - -80 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/op025615q

Reference yield:

4-(4-methoxylphenyl)pyridine (5938-16-9) → 2-methoxy-5-(4-pyridinyl)phenylboronic acid (196861-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine / 72 h / 60 °C / Inert atmosphere

2: n-butyllithium / tetrahydrofuran / 0.25 h / -85 - -80 °C / Inert atmosphere

With n-butyllithium; bromine; acetic acid; In tetrahydrofuran;

DOI:10.1021/op025615q

Reference yield:

4-chlorpyridine hydrochloride (7379-35-3) → 2-methoxy-5-(4-pyridinyl)phenylboronic acid (196861-33-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; toluene / 0.33 h / 0 - 5 °C / pH Ca_. 9

2.1: magnesium; iodine / tetrahydrofuran / 3 h / 35 °C / Inert atmosphere

2.2: 4.25 h / 30 - 45 °C / Inert atmosphere

3.1: acetic acid; bromine / 72 h / 60 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran / 0.25 h / -85 - -80 °C / Inert atmosphere

With n-butyllithium; bromine; iodine; magnesium; acetic acid; sodium hydroxide; In tetrahydrofuran; water; toluene;

DOI:10.1021/op025615q

upstream raw materials:

4-(4-methoxylphenyl)pyridine

triethyl borate

4-(3-bromo-4-methoxyphenyl)pyridine

4-chlorpyridine hydrochloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 196861-33-3 2-METHOXY-5-(PYRIDIN-4-YL)PHENYLBORONIC ACID

Send

Send

Metric Ton KG G Pound L ML

Send

Send