5-BROMO-2-METHYLBENZOIC ACID ETHYL ESTER

Base Information

• Chemical Name: 5-BROMO-2-METHYLBENZOIC ACID ETHYL ESTER
• CAS No.: 359629-91-7
• Molecular Formula: C₁₀H₁₁BrO₂
• Molecular Weight: 243.1
• Mol file: 359629-91-7.mol

Synonyms:ethyl 5-bromo-2-methylbenzoate

Chemical Property of 5-BROMO-2-METHYLBENZOIC ACID ETHYL ESTER

Chemical Property:

• Boiling Point: 276.0±20.0 °C(Predicted)
• Density: 1.378±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-2-methyl-benzoicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-METHYLBENZOIC ACID ETHYL ESTER

There total 4 articles about 5-BROMO-2-METHYLBENZOIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethanol (64-17-5) + 5-bromo-2-methylbenzoic acid (79669-49-1) → ethyl 5-bromo-2-methylbenzoate (359629-91-7)

Guidance literature:

With sulfuric acid; In benzene; Cooling with ice; Reflux;

DOI:10.1002/cjoc.201190222

Reference yield: 69.0%

ethyl 5-amino-2-methylbenzoate (7335-32-2) → ethyl 5-bromo-2-methylbenzoate (359629-91-7)

Guidance literature:

ethyl 5-amino-2-methylbenzoate; With hydrogen bromide; In water; Cooling with ice;

With hydrogen bromide; sodium nitrite; In water;

With hydrogen bromide; copper(I) bromide; In water; at 70 ℃; Cooling with ice;

Reference yield:

Br(1-)*C10H11N2O2(1+) → ethyl 5-bromo-2-methylbenzoate (359629-91-7)

Guidance literature:

With hydrogen bromide; copper(I) bromide; In water; at 0 - 70 ℃; for 1h;

upstream raw materials:

ethyl 5-amino-2-methylbenzoate

ethanol

5-bromo-2-methylbenzoic acid

Downstream raw materials:

ethyl 5-bromo-2-(bromomethyl)benzoate

ethyl 5-iodo-2-methylbenzoate

(5-iodo-2-methyl-phenyl)-methanol

C₂₄H₃₂O₆

Refernces

• 1、 -. "SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF USE". Paragraph 0227. . Retrieved 2014/06/24.
• 2、 -. "4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes". Paragraph 0565-0568; 0577. . Retrieved 2014/03/21.