4-(4-fluoro-2-(1-(3,3,3-trifluoropropylamino)propan-2-yloxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide

Base Information

Chemical Name:4-(4-fluoro-2-(1-(3,3,3-trifluoropropylamino)propan-2-yloxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide
CAS No.:1332758-80-1
Molecular Formula:C₂₀H₂₁F₄N₅O₂S
Molecular Weight:471.479
Hs Code.:

Synonyms:4-(4-fluoro-2-(1-(3,3,3-trifluoropropylamino)propan-2-yloxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide

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Chemical Property of 4-(4-fluoro-2-(1-(3,3,3-trifluoropropylamino)propan-2-yloxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide

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Technology Process of 4-(4-fluoro-2-(1-(3,3,3-trifluoropropylamino)propan-2-yloxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide

There total 8 articles about 4-(4-fluoro-2-(1-(3,3,3-trifluoropropylamino)propan-2-yloxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 460-40-2
3,3,3-trifluoropropanal

: 1332758-79-8
4-(2-(1-Aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate

: 1332758-80-1
4-(4-fluoro-2-(1-(3,3,3-trifluoropropylamino)propan-2-yloxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: With sodium cyanoborohydride; In tetrahydrofuran; at 20 ℃; for 96h; pH=5; buffer;

Reference yield:

: 460-40-2
3,3,3-trifluoropropanal

: 4-(2-(1-aminopropan-2-yloxy)-4-fluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate

: 1332758-80-1
4-(4-fluoro-2-(1-(3,3,3-trifluoropropylamino)propan-2-yloxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: 3,3,3-trifluoropropanal; 4-(2-(1-aminopropan-2-yloxy)-4-fluorophenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate; With sodium cyanoborohydride; In tetrahydrofuran; at 20 ℃; for 96h; buffer;

With water; In tetrahydrofuran;

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 1332758-80-1
4-(4-fluoro-2-(1-(3,3,3-trifluoropropylamino)propan-2-yloxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 100 °C

4.1: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 2 h

6.1: dichloromethane / 20 °C

7.1: sodium cyanoborohydride / tetrahydrofuran / 96 h / 20 °C / buffer

With methanol; di-tert-butyl-diazodicarboxylate; hydrogen; sodium cyanoborohydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Mitsunobu reaction;