4-(2-(1-Aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate

Base Information

Chemical Name:4-(2-(1-Aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate
CAS No.:1332758-79-8
Molecular Formula:C₂HF₃O₂*C₁₇H₁₈FN₅O₂S
Molecular Weight:489.451
Hs Code.:

Synonyms:4-(2-(1-Aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate

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Chemical Property of 4-(2-(1-Aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate

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Technology Process of 4-(2-(1-Aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate

There total 6 articles about 4-(2-(1-Aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332758-69-6
tert-Butyl 2-(2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate

: 76-05-1
trifluoroacetic acid

: 1332758-79-8
4-(2-(1-Aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃;

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 1332758-79-8
4-(2-(1-Aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 20 °C / Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 100 °C

4.1: sodium hydroxide / tetrahydrofuran; methanol / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 2 h

6.1: dichloromethane / 20 °C

With di-tert-butyl-diazodicarboxylate; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1332721-17-1
[2-(5-fluoro-2-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

: 1332758-79-8
4-(2-(1-Aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 100 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 2 h

5.1: dichloromethane / 20 °C

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;