(6aR^*,10aR^*,11R^*)-11-<<3-(4-phenyl-1-piperazinyl)propyl>amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin

Base Information

• Chemical Name: (6aR^*,10aR^*,11R^*)-11-<<3-(4-phenyl-1-piperazinyl)propyl>amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin
• CAS No.: 130933-50-5
• Molecular Formula: C₂₇H₃₇N₃S
• Molecular Weight: 435.677

Synonyms:(6aR^*,10aR^*,11R^*)-11-<<3-(4-phenyl-1-piperazinyl)propyl>amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin

Chemical Property of (6aR^*,10aR^*,11R^*)-11-<<3-(4-phenyl-1-piperazinyl)propyl>amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6aR^*,10aR^*,11R^*)-11-<<3-(4-phenyl-1-piperazinyl)propyl>amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin

There total 4 articles about (6aR^*,10aR^*,11R^*)-11-<<3-(4-phenyl-1-piperazinyl)propyl>amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

N-(4aS,5S,11aS)-1,2,3,4,4a,5,11,11a-Octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl-3-(4-phenyl-piperazin-1-yl)-propionamide (130933-47-0) → (6aR*,10aR*,11R*)-11-<<3-(4-phenyl-1-piperazinyl)propyl>amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin (130933-50-5)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 80 ℃; for 2h;

DOI:10.1021/jm00106a019

Reference yield:

4-phenyl-1-piperazine (92-54-6) → (6aR*,10aR*,11R*)-11-<<3-(4-phenyl-1-piperazinyl)propyl>amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin (130933-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI / dimethylformamide / 1 h / 100 °C

2: 33 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 2 h / 80 °C

With sodium bis(2-methoxyethoxy)aluminium dihydride; sodium iodide; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00106a019

Reference yield:

(6aR*,10aR*,11R*)-11-<(chloropropionyl)amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin (130933-43-6) → (6aR*,10aR*,11R*)-11-<<3-(4-phenyl-1-piperazinyl)propyl>amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin (130933-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI / dimethylformamide / 1 h / 100 °C

2: 33 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 2 h / 80 °C

With sodium bis(2-methoxyethoxy)aluminium dihydride; sodium iodide; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00106a019

upstream raw materials:

N-(4aS,5S,11aS)-1,2,3,4,4a,5,11,11a-Octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl-3-(4-phenyl-piperazin-1-yl)-propionamide

4-phenyl-1-piperazine

(6aR^*,10aR^*,11R^*)-11-<(chloropropionyl)amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin

trans(6a-H,10a-H)-cis(10a-H,11-H)-11-amino-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepine

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