1-[2-(2-bromo-5-methoxy-phenyl)-allyl]-7-methoxy-1-(3-methoxy-phenyl)-indan-2-one

Base Information

Chemical Name:1-[2-(2-bromo-5-methoxy-phenyl)-allyl]-7-methoxy-1-(3-methoxy-phenyl)-indan-2-one
CAS No.:884320-39-2
Molecular Formula:C₂₇H₂₅BrO₄
Molecular Weight:493.397
Hs Code.:

Synonyms:1-[2-(2-bromo-5-methoxy-phenyl)-allyl]-7-methoxy-1-(3-methoxy-phenyl)-indan-2-one

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Chemical Property of 1-[2-(2-bromo-5-methoxy-phenyl)-allyl]-7-methoxy-1-(3-methoxy-phenyl)-indan-2-one

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Technology Process of 1-[2-(2-bromo-5-methoxy-phenyl)-allyl]-7-methoxy-1-(3-methoxy-phenyl)-indan-2-one

There total 10 articles about 1-[2-(2-bromo-5-methoxy-phenyl)-allyl]-7-methoxy-1-(3-methoxy-phenyl)-indan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 884320-33-6
1-bromo-2-(3-iodoprop-1-en-2-yl)-4-methoxybenzene

: 884320-32-5
7-methoxy-1-(3-methoxyphenyl)-1H-inden-2(3H)-one

: 884320-39-2
1-[2-(2-bromo-5-methoxy-phenyl)-allyl]-7-methoxy-1-(3-methoxy-phenyl)-indan-2-one

Guidance literature:: 7-methoxy-1-(3-methoxyphenyl)-1H-inden-2(3H)-one; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 20 ℃; for 1h;

1-bromo-2-(3-iodoprop-1-en-2-yl)-4-methoxybenzene; In tetrahydrofuran; toluene; at 20 ℃; for 1h;
DOI:10.1021/ja0602997

Reference yield:

: 884320-42-7
2-(2-bromo-5-methoxyphenyl)prop-2-en-1-ol

: 884320-39-2
1-[2-(2-bromo-5-methoxy-phenyl)-allyl]-7-methoxy-1-(3-methoxy-phenyl)-indan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / Ph₃P; imidazole; I₂ / CH₂Cl₂ / 0.5 h / 0 °C

2.1: potassium hexamethylisilazide; DMPU / tetrahydrofuran; toluene / 1 h / 20 °C

2.2: 54 percent / tetrahydrofuran; toluene; various solvent(s) / 1 h / 20 °C

With 1H-imidazole; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; iodine; potassium hexamethylsilazane; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja0602997

Reference yield:

: 1006606-22-9
4-methoxy-3-(3-methoxyphenyl)-1H-indene

: 884320-39-2
1-[2-(2-bromo-5-methoxy-phenyl)-allyl]-7-methoxy-1-(3-methoxy-phenyl)-indan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methylmorpholine-N-oxide; OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 7.5 h / 20 °C

2.1: 40.4 g / p-toluenesulfonic acid / benzene / 6 h / Heating

3.1: potassium hexamethylisilazide; DMPU / tetrahydrofuran; toluene / 1 h / 20 °C

3.2: 54 percent / tetrahydrofuran; toluene; various solvent(s) / 1 h / 20 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; osmium(VIII) oxide; potassium hexamethylsilazane; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; acetone; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/ja0602997