17-(CYCLOPROPYLMETHYL)-6,7-DEHYDRO-4,5-EPOXY-3-BENZYLOXY-14-HYDROXY-6,7,2',3'-INDOLOMORPHINAN

Base Information

• Chemical Name: 17-(CYCLOPROPYLMETHYL)-6,7-DEHYDRO-4,5-EPOXY-3-BENZYLOXY-14-HYDROXY-6,7,2',3'-INDOLOMORPHINAN
• CAS No.: 161532-22-5
• Molecular Formula: C33H32 N2 O3
• Molecular Weight: 504.62
• Mol file: 161532-22-5.mol

Synonyms:4,8-Methanobenzofuro[2,3-a]pyrido[4,3-b]carbazol-8a(9H)-ol,7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-1-(phenylmethoxy)-, [8R-(4bS*,8a,8ab,14bb)]-

Chemical Property of 17-(CYCLOPROPYLMETHYL)-6,7-DEHYDRO-4,5-EPOXY-3-BENZYLOXY-14-HYDROXY-6,7,2',3'-INDOLOMORPHINAN

Chemical Property:

• PSA: 57.72000
• LogP: 5.38390

Purity/Quality:

99% ^*data from raw suppliers

17-(CYCLOPROPYLMETHYL)-6,7-DEHYDRO-4,5-EPOXY-3-BENZYLOXY-14-HYDROXY-6,7,2',3'-INDOLOMORPHINAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 17-(CYCLOPROPYLMETHYL)-6,7-DEHYDRO-4,5-EPOXY-3-BENZYLOXY-14-HYDROXY-6,7,2',3'-INDOLOMORPHINAN

There total 3 articles about 17-(CYCLOPROPYLMETHYL)-6,7-DEHYDRO-4,5-EPOXY-3-BENZYLOXY-14-HYDROXY-6,7,2',3'-INDOLOMORPHINAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

naltrindole (111555-53-4) + benzyl bromide (100-39-0) → 17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,7-2',3'-indolomorphinan (161532-22-5)

Guidance literature:

With potassium carbonate; In acetone; for 5h; Heating;

DOI:10.1002/jlcr.1095

Reference yield:

Naltrexone (16590-41-3) → 17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,7-2',3'-indolomorphinan (161532-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / K₂CO₃ / dimethylformamide

2: 58 percent / TsOH*H₂O / ethanol / Heating

With potassium carbonate; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide; 1: Condensation / 2: Cycloaddition;

DOI:10.1016/S0960-894X(99)00622-8

Reference yield:

benzyl bromide (100-39-0) → 17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,7-2',3'-indolomorphinan (161532-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / K₂CO₃ / dimethylformamide

2: 58 percent / TsOH*H₂O / ethanol / Heating

With potassium carbonate; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide; 1: Condensation / 2: Cycloaddition;

DOI:10.1016/S0960-894X(99)00622-8

upstream raw materials:

naltrindole

benzyl bromide

Naltrexone

Downstream raw materials:

17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-3-benzyloxy-14-hydroxy-6,7,2',3'-[1'-(p-fluorobenzyl)]-indolomorphinan

17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,7-2',3'-(1'-methyl)-indolomorphinan