17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-3-benzyloxy-14-hydroxy-6,7,2',3'-[1'-(p-fluorobenzyl)]-indolomorphinan

Base Information

• Chemical Name: 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-3-benzyloxy-14-hydroxy-6,7,2',3'-[1'-(p-fluorobenzyl)]-indolomorphinan
• CAS No.: 948906-06-7
• Molecular Formula: C₄₀H₃₇FN₂O₃
• Molecular Weight: 612.744
• Mol file: 948906-06-7.mol

Synonyms:17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-3-benzyloxy-14-hydroxy-6,7,2',3'-[1'-(p-fluorobenzyl)]-indolomorphinan

Chemical Property of 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-3-benzyloxy-14-hydroxy-6,7,2',3'-[1'-(p-fluorobenzyl)]-indolomorphinan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-3-benzyloxy-14-hydroxy-6,7,2',3'-[1'-(p-fluorobenzyl)]-indolomorphinan

There total 3 articles about 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-3-benzyloxy-14-hydroxy-6,7,2',3'-[1'-(p-fluorobenzyl)]-indolomorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.5%

4-Fluorobenzyl bromide (459-46-1) + 17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,7-2',3'-indolomorphinan (161532-22-5) → 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-3-benzyloxy-14-hydroxy-6,7,2',3'-[1'-(p-fluorobenzyl)]-indolomorphinan (948906-06-7)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/jlcr.1095

Reference yield:

naltrindole (111555-53-4) → 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-3-benzyloxy-14-hydroxy-6,7,2',3'-[1'-(p-fluorobenzyl)]-indolomorphinan (948906-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / K₂CO₃ / acetone / 5 h / Heating

2: 74.5 percent / tetrabutylammonium hydrogen sulfate; NaOH / CH₂Cl₂ / 2 h / 20 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In dichloromethane; acetone;

DOI:10.1002/jlcr.1095

Reference yield:

benzyl bromide (100-39-0) → 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-3-benzyloxy-14-hydroxy-6,7,2',3'-[1'-(p-fluorobenzyl)]-indolomorphinan (948906-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / K₂CO₃ / acetone / 5 h / Heating

2: 74.5 percent / tetrabutylammonium hydrogen sulfate; NaOH / CH₂Cl₂ / 2 h / 20 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In dichloromethane; acetone;

DOI:10.1002/jlcr.1095

upstream raw materials:

4-Fluorobenzyl bromide

17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3-benzyloxy-14-hydroxy-6,7-2',3'-indolomorphinan

naltrindole

benzyl bromide