4,4,5-trifluoro-2,5-bis(4-chlorophenyl)-4,5-dihydrothiazole

Base Information

• Chemical Name: 4,4,5-trifluoro-2,5-bis(4-chlorophenyl)-4,5-dihydrothiazole
• CAS No.: 1362243-70-6
• Molecular Formula: C₁₅H₈Cl₂F₃NS
• Molecular Weight: 362.202
• Mol file: 1362243-70-6.mol

Synonyms:4,4,5-trifluoro-2,5-bis(4-chlorophenyl)-4,5-dihydrothiazole

Chemical Property of 4,4,5-trifluoro-2,5-bis(4-chlorophenyl)-4,5-dihydrothiazole

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4,5-trifluoro-2,5-bis(4-chlorophenyl)-4,5-dihydrothiazole

There total 2 articles about 4,4,5-trifluoro-2,5-bis(4-chlorophenyl)-4,5-dihydrothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2,5-bis(4-chlorophenyl)-1,3-thiazole → 4,4,5-trifluoro-2,5-bis(4-chlorophenyl)-4,5-dihydrothiazole (1362243-70-6)

Guidance literature:

With Selectfluor; In acetonitrile; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.201405758

Reference yield:

4-Chlorophenylboronic acid (1679-18-1) → 4,4,5-trifluoro-2,5-bis(4-chlorophenyl)-4,5-dihydrothiazole (1362243-70-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium chloride; sodium carbonate / toluene; water; ethanol / 3 h / 100 °C / Inert atmosphere

2: Selectfluor / acetonitrile / 3 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium chloride; sodium carbonate; Selectfluor; In ethanol; water; toluene; acetonitrile; 1: |Suzuki Coupling;

DOI:10.1002/anie.201405758

upstream raw materials:

4-Chlorophenylboronic acid