(4R)-3-<3'-phenyl-2'(E)-propenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one

Base Information

Chemical Name:(4R)-3-<3'-phenyl-2'(E)-propenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one
CAS No.:168298-08-6
Molecular Formula:C₂₀H₁₉NO₃
Molecular Weight:321.376
Hs Code.:

Synonyms:(4R)-3-<3'-phenyl-2'(E)-propenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one

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Chemical Property of (4R)-3-<3'-phenyl-2'(E)-propenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one

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Technology Process of (4R)-3-<3'-phenyl-2'(E)-propenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one

There total 11 articles about (4R)-3-<3'-phenyl-2'(E)-propenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 100-52-7
benzaldehyde

: [2-((R)-5,5-Dimethyl-2-oxo-4-phenyl-oxazolidin-3-yl)-2-oxo-ethyl]-triphenyl-phosphonium; iodide

: 168298-08-6
(4R)-3-<3'-phenyl-2'(E)-propenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one

Guidance literature:: [2-((R)-5,5-Dimethyl-2-oxo-4-phenyl-oxazolidin-3-yl)-2-oxo-ethyl]-triphenyl-phosphonium; iodide; With sodium hydride; In dichloromethane; at 20 ℃; for 0.5h;

benzaldehyde; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1080/10426500490468155

Reference yield: 72.0%

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 170918-42-0
(R)-(-)-5,5-dimethyl-4-phenyl-2-oxazolidinone

: 168298-08-6
(4R)-3-<3'-phenyl-2'(E)-propenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1007/BF03245877

Reference yield:

: 875-74-1
(R)-phenylglycine

: 168298-08-6
(4R)-3-<3'-phenyl-2'(E)-propenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / SOCl₂ / 2 h / Heating

2: 41 percent / diethyl ether / 3 h

3: 82 percent / CH₂Cl₂ / 2 h / Heating

4: 1) n-BuLi / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 10 min; room temperature, 2 h

With n-butyllithium; thionyl chloride; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(98)01145-4