1-(4-FLUOROPHENYL)-2-METHYL-2-AMINOPROPANE HYDROCHLORIDE

Base Information

• Chemical Name: 1-(4-FLUOROPHENYL)-2-METHYL-2-AMINOPROPANE HYDROCHLORIDE
• CAS No.: 2413-54-9
• Molecular Formula: C10H14 F N . Cl H
• Molecular Weight: 203.687
• Hs Code.: 2921499090
• Mol file: 2413-54-9.mol

Synonyms:Benzeneethanamine,4-fluoro-a,a-dimethyl-, hydrochloride (9CI); Phenethylamine,p-fluoro-a,a-dimethyl-, hydrochloride (7CI,8CI);[2-(4-Fluorophenyl)-1,1-dimethylethyl]amine hydrochloride

Chemical Property of 1-(4-FLUOROPHENYL)-2-METHYL-2-AMINOPROPANE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.00661mmHg at 25°C
• Melting Point: 180 ºC
• Boiling Point: 266.8 °C at 760 mmHg
• Flash Point: 115.1 °C
• PSA: 26.02000
• LogP: 3.60780

Purity/Quality:

96% ^*data from raw suppliers

4-Fluoro-a,a-dimethylbenzeneethanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-FLUOROPHENYL)-2-METHYL-2-AMINOPROPANE HYDROCHLORIDE

There total 2 articles about 1-(4-FLUOROPHENYL)-2-METHYL-2-AMINOPROPANE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-[(dimethyl-4-fluorobenzylsilyl)methyl]phthalimide → dimethylparafluorobenzylmethanamine hydrochloride + 2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamine hydrochloride (2413-54-9)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; In ethanol;

Reference yield:

chloro-N-[2-(4-fluorophenyl)-1,1-dimethylethyl]acetamide → 2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamine hydrochloride (2413-54-9)

Guidance literature:

chloro-N-[2-(4-fluorophenyl)-1,1-dimethylethyl]acetamide; With thiourea; In ethanol; acetic acid; at 78 - 86 ℃; for 4h;

With hydrogenchloride; In water; toluene;

Reference yield:

2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamine hydrochloride (2413-54-9) + Fmoc-Glu(OtBu)-OH (71989-18-9) → 4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester (920289-27-6)

Guidance literature:

2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamine hydrochloride; Fmoc-Glu(OtBu)-OH; With 4-methyl-morpholine; isobutyl chloroformate; In toluene; at 5 - 15 ℃; for 1h;

With diethylamine; In water; toluene; at 20 ℃; for 2 - 12h; Product distribution / selectivity;

Downstream raw materials:

tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-[2-(4-fluorophenyl)-1,1-dimethylethyl]-L-α-glutaminate

4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester

4(S)-[(Biphenyl-4-carbonyl)-amino]-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid

1-(4-fluorophenyl)-2-methylpropan-2-amine

Refernces

• 1、 -. "Substituted silyl alkylene amines". . . Retrieved 2008/06/13.