4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester

Base Information

Chemical Name:4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester
CAS No.:920289-27-6
Molecular Formula:C₁₉H₂₉FN₂O₃
Molecular Weight:352.449
Hs Code.:

Synonyms:4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester

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Chemical Property of 4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester

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Technology Process of 4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester

There total 4 articles about 4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1200-27-7
1-(4-fluorophenyl)-2-methylpropan-2-amine

: 920289-27-6
4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester

Guidance literature:: Fmoc-Glu(OtBu)-OH; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 ℃; for 0.5h;

1-(4-fluorophenyl)-2-methylpropan-2-amine; In tetrahydrofuran; Product distribution / selectivity;

Reference yield:

: 920289-26-5
tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-[2-(4-fluorophenyl)-1,1-dimethylethyl]-L-α-glutaminate

: 920289-27-6
4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester

Guidance literature:: With diethylamine; In water; toluene; at 20 ℃; for 2 - 12h; Product distribution / selectivity;

Reference yield:

: 2413-54-9
2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamine hydrochloride

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 920289-27-6
4(S)-Amino-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylcarbamoyl]-butyric acid tert-butyl ester

Guidance literature:: 2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamine hydrochloride; Fmoc-Glu(OtBu)-OH; With 4-methyl-morpholine; isobutyl chloroformate; In toluene; at 5 - 15 ℃; for 1h;

With diethylamine; In water; toluene; at 20 ℃; for 2 - 12h; Product distribution / selectivity;