Ν-(3-(3-(8-chloro-9-(tetrahydro-2-hydropyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)propane-1-sulfonamide

Base Information

Chemical Name:Ν-(3-(3-(8-chloro-9-(tetrahydro-2-hydropyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)propane-1-sulfonamide
CAS No.:1437316-74-9
Molecular Formula:C₂₄H₂₄ClF₂N₇O₃S
Molecular Weight:564.015
Hs Code.:

Synonyms:Ν-(3-(3-(8-chloro-9-(tetrahydro-2-hydropyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)propane-1-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ν-(3-(3-(8-chloro-9-(tetrahydro-2-hydropyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)propane-1-sulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Ν-(3-(3-(8-chloro-9-(tetrahydro-2-hydropyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)propane-1-sulfonamide

There total 15 articles about Ν-(3-(3-(8-chloro-9-(tetrahydro-2-hydropyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1380228-80-7
N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide

: 1437316-74-9
Ν-(3-(3-(8-chloro-9-(tetrahydro-2-hydropyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)propane-1-sulfonamide

Guidance literature:: N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With hexachloroethane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

: 84832-01-9
methyl 2,6-difluoro-3-nitrobenzoate

: 1437316-74-9
Ν-(3-(3-(8-chloro-9-(tetrahydro-2-hydropyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2.1: pyridine / 1,2-dichloro-ethane / 5 h / 100 °C

3.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C

4.2: 80 °C

5.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 60 °C

6.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

6.2: 1 h / -78 °C / Inert atmosphere

With pyridine; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; sodium hexamethyldisilazane; triethylamine; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;

Reference yield:

: 84832-02-0
methyl 3-amino-2,6-difluorobenzoate

: 1437316-74-9
Ν-(3-(3-(8-chloro-9-(tetrahydro-2-hydropyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 1,2-dichloro-ethane / 5 h / 100 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C

3.2: 80 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 60 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

5.2: 1 h / -78 °C / Inert atmosphere

With pyridine; diphenyl phosphoryl azide; water; sodium hexamethyldisilazane; triethylamine; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dichloro-ethane;