N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide

Base Information

Chemical Name:N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide
CAS No.:1380228-80-7
Molecular Formula:C₂₄H₂₅F₂N₇O₃S
Molecular Weight:529.57
Hs Code.:

Synonyms:N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide

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Chemical Property of N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide

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Technology Process of N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide

There total 28 articles about N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 10147-36-1
n-propanesulfonyl chloride

: 1380228-73-8
2,6-difluoro-N₁-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)benzene-1,3-diamine

: 1380228-80-7
N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 50 ℃; for 2h;

Reference yield: 54.0%

: 1093101-52-0
6-(2-fluoropyridin-3-yl)-9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purine

: 1103234-57-6
N-(3-amino-2,4-difluorophenyl)propane-1-sulfonamide

: 1380228-80-7
N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 60 ℃; for 2h;

Reference yield:

: 385-00-2
2,6-difluorobenzoic acid

: 1380228-80-7
N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 2 h / Reflux

1.2: 2 h / 20 °C

2.1: sulfuric acid / 2 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

4.1: pyridine / 1,2-dichloro-ethane / 5 h / 100 °C

5.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

6.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C

6.2: 80 °C

7.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 60 °C

With pyridine; thionyl chloride; sulfuric acid; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; sodium hexamethyldisilazane; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;