Technology Process of (R)-3-(2-tetrahydropyranyloxy)-2-(p-methoxybenzyl)propyl acetate
There total 4 articles about (R)-3-(2-tetrahydropyranyloxy)-2-(p-methoxybenzyl)propyl acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridinium p-toluenesulfonate;
In
dichloromethane;
for 3h;
Ambient temperature;
DOI:10.3987/COM-95-7232
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 96 percent / 2,6-di-tert-butyl-p-cresole, Lipase PS / diisopropyl ether; H2O / 1.5 h / Ambient temperature
2: 97 percent / pyridinium p-tosylate / CH2Cl2 / 3 h / Ambient temperature
With
Lipase PS; 2,6-di-tert-butyl-4-methyl-phenol; pyridinium p-toluenesulfonate;
In
dichloromethane; di-isopropyl ether; water;
DOI:10.3987/COM-95-7232
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 74 percent / 1.) sodium hydride / 1.) mineral oil, THF, r.t., 30 min; 2.) THF, 4 h, reflux
2: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
3: 96 percent / 2,6-di-tert-butyl-p-cresole, Lipase PS / diisopropyl ether; H2O / 1.5 h / Ambient temperature
4: 97 percent / pyridinium p-tosylate / CH2Cl2 / 3 h / Ambient temperature
With
lithium aluminium tetrahydride; Lipase PS; 2,6-di-tert-butyl-4-methyl-phenol; pyridinium p-toluenesulfonate; sodium hydride;
In
tetrahydrofuran; dichloromethane; di-isopropyl ether; water;
DOI:10.3987/COM-95-7232
