C₂₂H₃₂I₂O

Base Information

• Chemical Name: C₂₂H₃₂I₂O
• CAS No.: 1453858-52-0
• Molecular Formula: C₂₂H₃₂I₂O
• Molecular Weight: 566.304
• Mol file: 1453858-52-0.mol

Synonyms:C₂₂H₃₂I₂O

Chemical Property of C₂₂H₃₂I₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₃₂I₂O

There total 7 articles about C₂₂H₃₂I₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1,3-di(hept-6-ynyl)-2-methoxy-5-methylbenzene (1453858-48-4) → C22H32I2O (1453858-52-0)

Guidance literature:

1,3-di(hept-6-ynyl)-2-methoxy-5-methylbenzene; With Schwartz's reagent; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere; Darkness;

With iodine; In dichloromethane; for 0.5h; Inert atmosphere; Darkness;

DOI:10.1002/anie.201206785

Reference yield:

1-acetoxy-2,6-dibromo-4-methoxyphenol (2423-74-7) → C22H32I2O (1453858-52-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium phosphate monohydrate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere; Schlenk technique

2.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 1 h / Inert atmosphere

3.1: Schwartz's reagent / dichloromethane / 0.25 h / 20 °C / Inert atmosphere; Darkness

3.2: 0.5 h / Inert atmosphere; Darkness

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; Schwartz's reagent; potassium phosphate monohydrate; tetrabutyl ammonium fluoride; water; palladium diacetate; In tetrahydrofuran; dichloromethane; 1.1: |Suzuki Coupling;

DOI:10.1002/anie.201206785

Reference yield:

trimethyl (hep-6-en-1-yn-1-yl)silane (94012-65-4) → C22H32I2O (1453858-52-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 2 h / 70 °C / Schlenk technique; Inert atmosphere

2.1: potassium phosphate monohydrate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere; Schlenk technique

3.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 1 h / Inert atmosphere

4.1: Schwartz's reagent / dichloromethane / 0.25 h / 20 °C / Inert atmosphere; Darkness

4.2: 0.5 h / Inert atmosphere; Darkness

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; Schwartz's reagent; potassium phosphate monohydrate; tetrabutyl ammonium fluoride; water; palladium diacetate; In tetrahydrofuran; dichloromethane; 2.1: |Suzuki Coupling;

DOI:10.1002/anie.201206785

upstream raw materials:

1,3-di(hept-6-ynyl)-2-methoxy-5-methylbenzene

1-acetoxy-2,6-dibromo-4-methoxyphenol

4-methoxy-phenol

trimethyl (hep-6-en-1-yn-1-yl)silane