TERT-BUTYL 4-BROMO-2-CHLOROPHENYLCARBAMATE

Base Information

• Chemical Name: TERT-BUTYL 4-BROMO-2-CHLOROPHENYLCARBAMATE
• CAS No.: 330794-09-7
• Molecular Formula: C11H13 Br Cl N O2
• Molecular Weight: 306.587
• Hs Code.: 2924299090
• Mol file: 330794-09-7.mol

Synonyms:tert-ButylN-(4-bromo-2-chlorophenyl)carbamate

Chemical Property of TERT-BUTYL 4-BROMO-2-CHLOROPHENYLCARBAMATE

Chemical Property:

• Boiling Point: 302.7 °C at 760 mmHg
• Flash Point: 136.9 °C
• PSA: 38.33000
• Density: 1.484 g/cm³
• LogP: 4.52250
• Water Solubility.: at 25 deg C (mg/L): 1.205

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl(4-bromo-2-chlorophenyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-BROMO-2-CHLOROPHENYLCARBAMATE

There total 3 articles about TERT-BUTYL 4-BROMO-2-CHLOROPHENYLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyl (4-bromophenyl)carbamate (131818-17-2) → tert-butyl-N-(4-bromo-2-chlorophenyl)carbamate (330794-09-7)

Guidance literature:

With 1,3-dichloro-5,5-dimethylhydantoin; diisopropylamine hydrochloride; In toluene; at 25 ℃; for 14h; regioselective reaction; Darkness; Green chemistry;

DOI:10.1002/anie.201607388

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-chloro-4-bromoaniline (38762-41-3) → tert-butyl-N-(4-bromo-2-chlorophenyl)carbamate (330794-09-7)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; n-heptane; ethyl acetate;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-bromo-aniline (106-40-1) → tert-butyl-N-(4-bromo-2-chlorophenyl)carbamate (330794-09-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran

2: diisopropylamine hydrochloride; 1,3-dichloro-5,5-dimethylhydantoin / toluene / 14 h / 25 °C / Darkness; Green chemistry

With 1,3-dichloro-5,5-dimethylhydantoin; diisopropylamine hydrochloride; In tetrahydrofuran; toluene;

DOI:10.1002/anie.201607388

upstream raw materials:

di-tert-butyl dicarbonate

2-chloro-4-bromoaniline

4-bromo-aniline

tert-butyl (4-bromophenyl)carbamate

Downstream raw materials:

2-chloro-4-(3-methylpyrazin-2-yl)aniline

[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]boronic acid

Refernces

• 1、 -. "SERINE/THREONINE KINASE INHIBITORS". Paragraph 0260. . Retrieved 2015/02/19.
• 2、 -. "Pyrazolopyrimidines as therapeutic agents". Page/Page column 59. . Retrieved 2010/11/30.