TERT-BUTYL 4-IODO-2-METHYLPHENYLCARBAMATE

Base Information

• Chemical Name: TERT-BUTYL 4-IODO-2-METHYLPHENYLCARBAMATE
• CAS No.: 666746-27-6
• Molecular Formula: C12H16 I N O2
• Molecular Weight: 333.169
• Mol file: 666746-27-6.mol

Synonyms:Carbamicacid, (4-iodo-2-methylphenyl)-, 1,1-dimethylethyl ester (9CI);(4-Iodo-2-methylphenyl)carbamic acid tert-butyl ester;4-Iodo-2-methylcarbanilic acid tert-butyl ester

Chemical Property of TERT-BUTYL 4-IODO-2-METHYLPHENYLCARBAMATE

Chemical Property:

• Boiling Point: 310.6 °C at 760 mmHg
• Flash Point: 141.7 °C
• PSA: 38.33000
• Density: 1.536 g/cm³
• LogP: 4.01960
• Storage Temp.: 2-8°C(protect from light)
• Water Solubility.: at 25 deg C (mg/L): 0.5886

Purity/Quality:

99% ^*data from raw suppliers

N-BOC-4-iodo-2-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-IODO-2-METHYLPHENYLCARBAMATE

There total 1 articles about TERT-BUTYL 4-IODO-2-METHYLPHENYLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-iodo-2-methylaniline (13194-68-8) → (4-iodo-2-methyl-phenyl)-carbamic acid tert-butyl ester (666746-27-6)

Guidance literature:

In toluene; at 80 ℃; for 16h;

Reference yield: 71.0%

(4-iodo-2-methyl-phenyl)-carbamic acid tert-butyl ester (666746-27-6) + dimethylglyoxal (431-03-8) → tert-butyl(4-acetyl-2-methylphenyl)carbamate

Guidance literature:

With N-methylcyclohexylamine; at 30 ℃; for 25h; Molecular sieve; UV-irradiation;

DOI:10.1002/ejoc.201801650

Reference yield: 70.0%

(4-iodo-2-methyl-phenyl)-carbamic acid tert-butyl ester (666746-27-6) + 1-trimethylsilyl-1-pentyne (18270-17-2) → (2-methyl-4-pent-1-ynyl-phenyl)-carbamic acid tert-butyl ester

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl-ammonium chloride; silver carbonate; In tetrahydrofuran; at 60 ℃; for 20h; Inert atmosphere; Sealed tube;

upstream raw materials:

di-tert-butyl dicarbonate

4-iodo-2-methylaniline

Downstream raw materials:

t-butyl 4-(3-oxo-1-butenyl)-2-methylcarbanilate

2-methyl-4-(1-trifluoromethylethenyl)aniline

[2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]carbamic acid tert-butyl ester

t-butyl 2-methyl-4-trifluoroacetylcarbanilate

Refernces

• 1、 -. "SUBSTITUTED BENZANILIDE COMPOUND AND PEST CONTROL AGENT". Page/Page column 499. . Retrieved 2010/02/11.