Ethyl 4-(benzyloxycarbonylamino)-3-oxobutanoate

Base Information

Chemical Name:Ethyl 4-(benzyloxycarbonylamino)-3-oxobutanoate
CAS No.:67706-69-8
Molecular Formula:C14H17 N O5
Molecular Weight:279.293
Hs Code.:
DSSTox Substance ID:DTXSID90437624
Nikkaji Number:J1.099.357A
Wikidata:Q82253159

Synonyms:67706-69-8;ETHYL 4-(BENZYLOXYCARBONYLAMINO)-3-OXOBUTANOATE;Ethyl 4-(((benzyloxy)carbonyl)amino)-3-oxobutanoate;ethyl 3-oxo-4-(phenylmethoxycarbonylamino)butanoate;ETHYL 4-{[(BENZYLOXY)CARBONYL]AMINO}-3-OXOBUTANOATE;SCHEMBL3823557;DTXSID90437624;YTNLTCWHKVPONV-UHFFFAOYSA-N;Butanoic acid,3-oxo-4-[[(phenylmethoxy)carbonyl]amino]-, ethyl ester;Ethyl 4-(Cbz-amino)-3-oxobutanoate;MFCD08703136;BS-24792;CS-0434295;ethyl 4-benzyloxycarbonylamino-3-oxobutyrate;ethyl 4-benzyloxycarbonylamino-3-oxo-butyrate;3-Oxo-4-(benzyloxycarbonylamino)butanoic acid ethyl ester;Butanoic acid,3-oxo-4-[[(phenylmethoxy)carbonyl]amino]-,ethyl ester

Suppliers and Price of Ethyl 4-(benzyloxycarbonylamino)-3-oxobutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl4-(((benzyloxy)carbonyl)amino)-3-oxobutanoate 97%
1g
$ 301.00

American Custom Chemicals Corporation
ETHYL-4-(BENZYLOXYCARBONYLAMINO)-3-OXOBUTANOATE 95.00%
5MG
$ 498.82

Acrotein
Ethyl4-(Cbz-amino)-3-oxobutanoate 97%
1g
$ 366.67

Acrotein
Ethyl4-(Cbz-amino)-3-oxobutanoate 97%
0.25g
$ 165.00

Total 5 raw suppliers

Chemical Property of Ethyl 4-(benzyloxycarbonylamino)-3-oxobutanoate

Chemical Property:

Boiling Point:425.7 °C at 760 mmHg
PKA:10.12±0.46(Predicted)
Flash Point:211.3 °C
PSA：81.70000
Density:1.192 g/cm³
LogP:1.82600
Water Solubility.:at 25 deg C (mg/L): 1053
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:279.11067264
Heavy Atom Count:20
Complexity:337

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-(((benzyloxy)carbonyl)amino)-3-oxobutanoate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC(=O)CNC(=O)OCC1=CC=CC=C1

Technology Process of Ethyl 4-(benzyloxycarbonylamino)-3-oxobutanoate

There total 6 articles about Ethyl 4-(benzyloxycarbonylamino)-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.3%

: 67706-69-8
ethyl 4-Benzyloxycarbonylamino-3-oxobutanoate

Guidance literature:

Reference yield: 60.0%

: 6148-64-7
ethyl potassium malonate

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 67706-69-8
ethyl 4-Benzyloxycarbonylamino-3-oxobutanoate

Guidance literature:: N-(Benzyloxycarbonyl)glycine; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 2.5h;

ethyl potassium malonate; With magnesium chloride; In tetrahydrofuran; at 50 ℃; for 48h; Cooling with ice;

Reference yield:

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 67706-69-8
ethyl 4-Benzyloxycarbonylamino-3-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 12 h / Ambient temperature

2: 1.) propan-2-ylmagnesium bromide / 1.) THF, r.t., 0.5 h; r.t. to 40 deg C, 0.5 h, 2.) THF, r.t., 4 h

With isopropylmagnesium bromide; In tetrahydrofuran;