2-chloro-N-(2-chloro-6-fluorobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide

Base Information

Chemical Name:2-chloro-N-(2-chloro-6-fluorobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide
CAS No.:1365992-46-6
Molecular Formula:C₁₉H₈Cl₂F₄N₂O₂
Molecular Weight:443.184
Hs Code.:

Synonyms:2-chloro-N-(2-chloro-6-fluorobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide

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Chemical Property of 2-chloro-N-(2-chloro-6-fluorobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide

Chemical Property:

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Technology Process of 2-chloro-N-(2-chloro-6-fluorobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide

There total 1 articles about 2-chloro-N-(2-chloro-6-fluorobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 159783-22-9
3,5-difluoropyridin-4-ylamine

: 79455-63-3
2-chloro-6-fluorobenzoyl chloride

: 1365992-45-5
2-chloro-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide

: 1365992-46-6
2-chloro-N-(2-chloro-6-fluorobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide

Guidance literature:: 3,5-difluoropyridin-4-ylamine; 2-chloro-6-fluorobenzoyl chloride; With pyridine; at 0 ℃; for 3.16667h; Inert atmosphere;

With hydrogenchloride; In water; at 20 ℃; for 2h;

Reference yield:

: 1365992-46-6
2-chloro-N-(2-chloro-6-fluorobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide

: 1365992-45-5
2-chloro-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide

Guidance literature:: 2-chloro-N-(2-chloro-6-fluorobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide; With methanol; sodium hydroxide; at 20 - 80 ℃; for 5h;

With hydrogenchloride; In methanol;

Reference yield:

: 1365992-46-6
2-chloro-N-(2-chloro-6-fluorobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-fluorobenzamide

: 1365992-62-6
[2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide; methanol / 5 h / 20 - 80 °C

2.1: thionyl chloride / 18 h / 100 °C

3.1: thiourea; pyridine / isopropyl alcohol / 4 h / 85 °C / Inert atmosphere

3.2: 18 h / 85 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5.05 h / 0 - 20 °C / Inert atmosphere

5.1: trichlorophosphate / 18.75 h / 20 °C / Reflux

6.1: trimethylsilyl bromide / propiononitrile / 20 - 85 °C / Inert atmosphere

7.1: potassium phosphate / 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 70 °C / Inert atmosphere

With pyridine; methanol; potassium phosphate; thionyl chloride; trimethylsilyl bromide; thiourea; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In dichloromethane; water; isopropyl alcohol; toluene; propiononitrile;