1′-β-[7-(2,4-bis-benzyloxy-5-benzyloxymethypyrrolo[3,2-d]pyrimidine)]-2′-deoxyribofuranose

Base Information

Chemical Name:1′-β-[7-(2,4-bis-benzyloxy-5-benzyloxymethypyrrolo[3,2-d]pyrimidine)]-2′-deoxyribofuranose
CAS No.:1446175-13-8
Molecular Formula:C₃₃H₃₃N₃O₆
Molecular Weight:567.642
Hs Code.:

Synonyms:1′-β-[7-(2,4-bis-benzyloxy-5-benzyloxymethypyrrolo[3,2-d]pyrimidine)]-2′-deoxyribofuranose

Suppliers and Price of 1′-β-[7-(2,4-bis-benzyloxy-5-benzyloxymethypyrrolo[3,2-d]pyrimidine)]-2′-deoxyribofuranose

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1′-β-[7-(2,4-bis-benzyloxy-5-benzyloxymethypyrrolo[3,2-d]pyrimidine)]-2′-deoxyribofuranose

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1′-β-[7-(2,4-bis-benzyloxy-5-benzyloxymethypyrrolo[3,2-d]pyrimidine)]-2′-deoxyribofuranose

There total 5 articles about 1′-β-[7-(2,4-bis-benzyloxy-5-benzyloxymethypyrrolo[3,2-d]pyrimidine)]-2′-deoxyribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1446175-10-5
2,4-bis-benzyloxy-5-N-benzyloxymethy-7-(β-D-glycero-pentofuran-3′-ulos-1′-yl)pyrrolo[3,2-d]pyrimidine

: 1446175-13-8
1′-β-[7-(2,4-bis-benzyloxy-5-benzyloxymethypyrrolo[3,2-d]pyrimidine)]-2′-deoxyribofuranose

Guidance literature:: With sodium tris(acetoxy)borohydride; In acetic acid; acetonitrile; at -10 - 20 ℃; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jo400913k

Reference yield:

: 1446175-04-7
7-iodo-2,4-bis-benzyloxy-5H-pyrrolo[3,2-d]-pyrimidine

: 1446175-13-8
1′-β-[7-(2,4-bis-benzyloxy-5-benzyloxymethypyrrolo[3,2-d]pyrimidine)]-2′-deoxyribofuranose

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 48 h / 40 °C

3.1: sodium tris(acetoxy)borohydride / acetonitrile; acetic acid / -10 - 20 °C / Inert atmosphere

With tetrabutyl-ammonium chloride; palladium diacetate; sodium tris(acetoxy)borohydride; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; acetonitrile; mineral oil; 2.1: |Heck Reaction;
DOI:10.1021/jo400913k

Reference yield:

: 1446175-07-0
2,4-bis-benzyloxy-5-N-(benzyloxymethyl)-7-iodopyrrolo-[3,2-d]pyrimidine

: 1446175-13-8
1′-β-[7-(2,4-bis-benzyloxy-5-benzyloxymethypyrrolo[3,2-d]pyrimidine)]-2′-deoxyribofuranose

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 48 h / 40 °C

2: sodium tris(acetoxy)borohydride / acetonitrile; acetic acid / -10 - 20 °C / Inert atmosphere

With tetrabutyl-ammonium chloride; palladium diacetate; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; In acetic acid; N,N-dimethyl-formamide; acetonitrile; 1: |Heck Reaction;
DOI:10.1021/jo400913k