2,4-bis-benzyloxy-5-N-(benzyloxymethyl)-7-iodopyrrolo-[3,2-d]pyrimidine

Base Information

Chemical Name:2,4-bis-benzyloxy-5-N-(benzyloxymethyl)-7-iodopyrrolo-[3,2-d]pyrimidine
CAS No.:1446175-07-0
Molecular Formula:C₂₈H₂₄IN₃O₃
Molecular Weight:577.421
Hs Code.:

Synonyms:2,4-bis-benzyloxy-5-N-(benzyloxymethyl)-7-iodopyrrolo-[3,2-d]pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4-bis-benzyloxy-5-N-(benzyloxymethyl)-7-iodopyrrolo-[3,2-d]pyrimidine

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Technology Process of 2,4-bis-benzyloxy-5-N-(benzyloxymethyl)-7-iodopyrrolo-[3,2-d]pyrimidine

There total 2 articles about 2,4-bis-benzyloxy-5-N-(benzyloxymethyl)-7-iodopyrrolo-[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3587-60-8
Benzyloxymethyl chloride

: 1446175-04-7
7-iodo-2,4-bis-benzyloxy-5H-pyrrolo[3,2-d]-pyrimidine

: 1446175-07-0
2,4-bis-benzyloxy-5-N-(benzyloxymethyl)-7-iodopyrrolo-[3,2-d]pyrimidine

Guidance literature:: 7-iodo-2,4-bis-benzyloxy-5H-pyrrolo[3,2-d]-pyrimidine; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

Benzyloxymethyl chloride; In tetrahydrofuran; mineral oil; for 1h; Inert atmosphere;
DOI:10.1021/jo400913k

Reference yield:

: 222631-56-3
2,4-bis-benzyloxy-5H-pyrrolo[3,2-d]pyrimidine

: 1446175-07-0
2,4-bis-benzyloxy-5-N-(benzyloxymethyl)-7-iodopyrrolo-[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-iodo-succinimide / dichloromethane / Inert atmosphere

2.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

With N-iodo-succinimide; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1021/jo400913k

Reference yield: 76.0%

: 1446175-07-0
2,4-bis-benzyloxy-5-N-(benzyloxymethyl)-7-iodopyrrolo-[3,2-d]pyrimidine

: 130277-32-6
((2R,3S)-3-(tert-butyldiphenylsilyloxy)-2,3-dihydrofuran-2-yl)methanol

: 1446175-10-5
2,4-bis-benzyloxy-5-N-benzyloxymethy-7-(β-D-glycero-pentofuran-3′-ulos-1′-yl)pyrrolo[3,2-d]pyrimidine

Guidance literature:: With tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 40 ℃; for 48h;
DOI:10.1021/jo400913k