2,4-bis-benzyloxy-5-N-benzyloxymethy-7-(β-D-glycero-pentofuran-3′-ulos-1′-yl)pyrrolo[3,2-d]pyrimidine

Base Information

Chemical Name:2,4-bis-benzyloxy-5-N-benzyloxymethy-7-(β-D-glycero-pentofuran-3′-ulos-1′-yl)pyrrolo[3,2-d]pyrimidine
CAS No.:1446175-10-5
Molecular Formula:C₃₃H₃₁N₃O₆
Molecular Weight:565.626
Hs Code.:

Synonyms:2,4-bis-benzyloxy-5-N-benzyloxymethy-7-(β-D-glycero-pentofuran-3′-ulos-1′-yl)pyrrolo[3,2-d]pyrimidine

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Chemical Property of 2,4-bis-benzyloxy-5-N-benzyloxymethy-7-(β-D-glycero-pentofuran-3′-ulos-1′-yl)pyrrolo[3,2-d]pyrimidine

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Technology Process of 2,4-bis-benzyloxy-5-N-benzyloxymethy-7-(β-D-glycero-pentofuran-3′-ulos-1′-yl)pyrrolo[3,2-d]pyrimidine

There total 5 articles about 2,4-bis-benzyloxy-5-N-benzyloxymethy-7-(β-D-glycero-pentofuran-3′-ulos-1′-yl)pyrrolo[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1446175-07-0
2,4-bis-benzyloxy-5-N-(benzyloxymethyl)-7-iodopyrrolo-[3,2-d]pyrimidine

: 130277-32-6
((2R,3S)-3-(tert-butyldiphenylsilyloxy)-2,3-dihydrofuran-2-yl)methanol

: 1446175-10-5
2,4-bis-benzyloxy-5-N-benzyloxymethy-7-(β-D-glycero-pentofuran-3′-ulos-1′-yl)pyrrolo[3,2-d]pyrimidine

Guidance literature:: With tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 40 ℃; for 48h;
DOI:10.1021/jo400913k

Reference yield:

: 1446175-17-2
C₄₉H₄₉N₃O₆Si

: 1446175-10-5
2,4-bis-benzyloxy-5-N-benzyloxymethy-7-(β-D-glycero-pentofuran-3′-ulos-1′-yl)pyrrolo[3,2-d]pyrimidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jo400913k

Reference yield:

: 222631-56-3
2,4-bis-benzyloxy-5H-pyrrolo[3,2-d]pyrimidine

: 1446175-10-5
2,4-bis-benzyloxy-5-N-benzyloxymethy-7-(β-D-glycero-pentofuran-3′-ulos-1′-yl)pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-iodo-succinimide / dichloromethane / Inert atmosphere

2.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 48 h / 40 °C

With N-iodo-succinimide; tetrabutyl-ammonium chloride; palladium diacetate; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil; 3.1: |Heck Reaction;
DOI:10.1021/jo400913k