6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

Base Information

• Chemical Name: 6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde
• CAS No.: 1070653-31-4
• Molecular Formula: C₁₂H₅ClF₃N₃OS
• Molecular Weight: 331.705

Synonyms:6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

Chemical Property of 6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

Chemical Property:

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Technology Process of 6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

There total 1 articles about 6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-trifluoromethyl-6-(4'-chlorophenyl)imidazo<2,1-b><1,3,4>thiadiazole → 6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde (1070653-31-4)

Guidance literature:

With trichlorophosphate; at 0 - 60 ℃; for 4.5h;

DOI:10.1016/j.bmcl.2012.01.052

Reference yield: 96.0%

6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde (1070653-31-4) + 4-Nitrophenacyl bromide (99-81-0) + thiosemicarbazide (79-19-6) → 1-((6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl)methylene)-2-(4-(4-nitro phenyl)thiazol-2-yl)hydrazine

Guidance literature:

With 1-n-butyl-3-methylimidazolim bromide; In ethanol; at 80 ℃; for 0.5h;

DOI:10.1039/c5md00346f

Reference yield: 95.0%

6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde (1070653-31-4) + thiosemicarbazide (79-19-6) + 2-bromo-4'-fluoroacetophenone (403-29-2) → 1-((6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl)methylene)-2-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine

Guidance literature:

With 1-n-butyl-3-methylimidazolim bromide; In ethanol; at 80 ℃; for 0.5h;

DOI:10.1039/c5md00346f

upstream raw materials:

N,N-dimethyl-formamide

Downstream raw materials:

5-((6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)thiazolidine-2,4-dione

5-((6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)-2-thioxothiazolidin-4-one

2-((5Z)-5-((6-(4-chlorophenyl)-2-(trifluoromethyl)imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid

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