(R)-2-Chloro-1-phenylethanol

Base Information

Chemical Name:(R)-2-Chloro-1-phenylethanol
CAS No.:56751-12-3
Molecular Formula:C8H9ClO
Molecular Weight:156.612
Hs Code.:2906299090
European Community (EC) Number:676-601-2
UNII:K8JK8F8P2H
Nikkaji Number:J736.623J
Wikidata:Q27894094
Mol file:56751-12-3.mol

Synonyms:(R)-2-Chloro-1-phenylethanol;56751-12-3;(R)-(-)-2-Chloro-1-phenylethanol;(1R)-2-chloro-1-phenylethanol;K8JK8F8P2H;(-)-2-chloro-1-phenylethanol;2-Chloro-1-phenylethanol, (-)-;MFCD00077691;(1R)-2-Chloro-1-phenyl-ethanol;UNII-K8JK8F8P2H;SCHEMBL932391;R(-)-2-chloro-1-phenylethanol;XWCQSILTDPAWDP-QMMMGPOBSA-N;(R)-(?)-2-Chloro-1-phenylethanol;AKOS006377007;DS-17630;(R)-(?)-|A-(Chloromethyl)benzenemethanol;(R)-(-)-2-Chloro-1-phenylethanol, 97%;C3561;CS-0156604;D83182;(R)-.ALPHA.-(CHLOROMETHYL)BENZENEMETHANOL;(R)-.ALPHA.-(CHLOROMETHYL)BENZYL ALCOHOL;(.ALPHA.R)-.ALPHA.-CHLOROMETHYLBENZENEMETHANOL;Q27894094;BENZENEMETHANOL, .ALPHA.-(CHLOROMETHYL)-, (.ALPHA.R)-;(R)-(-)-2-Chloro-1-phenylethanol, purum, >=97.0% (sum of enantiomers, GC)

Suppliers and Price of (R)-2-Chloro-1-phenylethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)?-?(-?)?-?2-?Chloro-?1-?phenylethanol
1g
$ 125.00

TCI Chemical
(R)-(-)-2-Chloro-1-phenylethanol
25G
$ 291.00

TCI Chemical
(R)-(-)-2-Chloro-1-phenylethanol
5G
$ 59.00

Sigma-Aldrich
(R)-(?)-2-Chloro-1-phenylethanol 97%
1ml
$ 146.00

Crysdot
(R)-2-Chloro-1-phenylethanol 98%
10g
$ 223.00

ChemScene
(R)-2-Chloro-1-phenylethanol
100g
$ 571.00

ChemScene
(R)-2-Chloro-1-phenylethanol
25g
$ 169.00

Chem-Impex
(R)-(-)-2-Chloro-1-phenylethanol,98%(GC) 98%(GC)
5G
$ 124.32

Chem-Impex
(R)-(-)-2-Chloro-1-phenylethanol,98%(GC) 98%(GC)
25G
$ 478.24

American Custom Chemicals Corporation
(R)-(-)-2-CHLORO-1-PHENYLETHANOL 95.00%
1ML
$ 800.99

Total 55 raw suppliers

Chemical Property of (R)-2-Chloro-1-phenylethanol

Chemical Property:

Refractive Index:n20/D 1.552(lit.)
Boiling Point:254.9 °C at 760 mmHg
PKA:13.21±0.20(Predicted)
Flash Point:114.2 °C
PSA：20.23000
Density:1.187 g/cm³
LogP:1.95880
Storage Temp.:2-8°C
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:156.0341926
Heavy Atom Count:10
Complexity:89.3

Purity/Quality:

99%, ^*data from raw suppliers

(R)?-?(-?)?-?2-?Chloro-?1-?phenylethanol ^*data from reagent suppliers

Safty Information:

Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.;
Hazard Codes:R36/37/38:Irritating to eyes, respiratory system and skin.;
Statements: 36/37/38
Safety Statements: 23-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(CCl)O
Isomeric SMILES:C1=CC=C(C=C1)[C@H](CCl)O
Uses (R)?-?(-?)?-?2-?Chloro-?1-?phenylethanol is a building block used in the syn-?3,?5-?Dihydroxy Hexanoate which is an important side chain in the cholesterol reducing drug Atorvastatin (A791750).

Technology Process of (R)-2-Chloro-1-phenylethanol

There total 40 articles about (R)-2-Chloro-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 532-27-4,108321-66-0,164322-25-2
1-chloroacetophenone

: 56751-12-3
2-chloro-1-phenylethanol

Guidance literature:: With hydrogen; catalyst prepared from Ru[(S,S)-Tsdpen](p-cymene) and HBF₄; In methanol; tert-butyl alcohol; at 30 ℃; for 24h; under 38002.6 Torr; Product distribution / selectivity;

Reference yield: 48.0%

: 108-22-5
Isopropenyl acetate

: 532-27-4,108321-66-0,164322-25-2
1-chloroacetophenone

: 56751-12-3
2-chloro-1-phenylethanol

: 103665-43-6
(S)-1-acetoxy-1-phenyl-2-chloroethane

Guidance literature:: 1-chloroacetophenone; With aluminum oxide; sodium tetrahydroborate; In hexane; at 40 ℃; for 3h;

Isopropenyl acetate; With Lipase 'Amano' PS-C II; In hexane; at 25 ℃; for 10h;
DOI:10.1016/S0957-4166(02)00170-2

Reference yield: 43.0%

: 108-05-4,9003-20-7
vinyl acetate

: 1674-30-2
1-phenyl-2-chloroethanol

: 70111-05-6
(S)-2-chloro-1-phenylethanol

: 56751-12-3
2-chloro-1-phenylethanol

: 103665-43-6
(S)-1-acetoxy-1-phenyl-2-chloroethane

Guidance literature:: 1-phenyl-2-chloroethanol; With Burkholderia cepacia lipase; In diethyl ether; at 30 ℃; for 0.5h; Enzymatic reaction;

vinyl acetate; In diethyl ether; at 30 ℃; for 2.5h; optical yield given as %ee; enantioselective reaction; Enzymatic reaction;
DOI:10.1016/j.tet.2009.09.058