2-[(4-Benzyloxy-3-methyl-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol

Base Information

• Chemical Name: 2-[(4-Benzyloxy-3-methyl-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol
• CAS No.: 156079-18-4
• Molecular Formula: C₁₈H₂₃NO₃
• Molecular Weight: 301.386
• Mol file: 156079-18-4.mol

Synonyms:2-[(4-Benzyloxy-3-methyl-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol

Chemical Property of 2-[(4-Benzyloxy-3-methyl-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[(4-Benzyloxy-3-methyl-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol

There total 2 articles about 2-[(4-Benzyloxy-3-methyl-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzyl bromide (100-39-0) + 4-[Bis-(2-hydroxy-ethyl)-amino]-2-methyl-phenol (156079-11-7) → 2-[(4-Benzyloxy-3-methyl-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol (156079-18-4)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Heating;

DOI:10.1021/jm00026a013

Reference yield:

4-amino-2-methylphenol (2835-96-3) → 2-[(4-Benzyloxy-3-methyl-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol (156079-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / aq. AcOH / 48 h / Ambient temperature

2: 87 percent / KOH / ethanol / 2 h / Heating

With potassium hydroxide; acetic acid; In ethanol;

DOI:10.1021/jm00026a013

Reference yield: 34.0%

2-[(4-Benzyloxy-3-methyl-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol (156079-18-4) → (4-Benzyloxy-3-methyl-phenyl)-bis-(2-chloro-ethyl)-amine (156078-86-3)

Guidance literature:

With pyridine; methanesulfonyl chloride; at 70 ℃; for 0.25h;

DOI:10.1021/jm00026a013

upstream raw materials:

benzyl bromide

4-[Bis-(2-hydroxy-ethyl)-amino]-2-methyl-phenol

4-amino-2-methylphenol

Downstream raw materials:

(4-Benzyloxy-3-methyl-phenyl)-bis-(2-chloro-ethyl)-amine

Carbonic acid 4-[bis-(2-chloro-ethyl)-amino]-2-methyl-phenyl ester 4-nitro-phenyl ester

(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2-methyl-phenoxycarbonylamino}-pentanedioic acid

(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2-methyl-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester