(S)-tert-butyl 3-(hydroxymethyl)-4-(2-(3-nitrophenyl)-2-oxoethyl)piperazine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 3-(hydroxymethyl)-4-(2-(3-nitrophenyl)-2-oxoethyl)piperazine-1-carboxylate
CAS No.:1443739-27-2
Molecular Formula:C₁₈H₂₅N₃O₆
Molecular Weight:379.413
Hs Code.:

Synonyms:(S)-tert-butyl 3-(hydroxymethyl)-4-(2-(3-nitrophenyl)-2-oxoethyl)piperazine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl 3-(hydroxymethyl)-4-(2-(3-nitrophenyl)-2-oxoethyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of (S)-tert-butyl 3-(hydroxymethyl)-4-(2-(3-nitrophenyl)-2-oxoethyl)piperazine-1-carboxylate

There total 1 articles about (S)-tert-butyl 3-(hydroxymethyl)-4-(2-(3-nitrophenyl)-2-oxoethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 314741-40-7
(3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 1443739-27-2
(S)-tert-butyl 3-(hydroxymethyl)-4-(2-(3-nitrophenyl)-2-oxoethyl)piperazine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1443739-27-2
(S)-tert-butyl 3-(hydroxymethyl)-4-(2-(3-nitrophenyl)-2-oxoethyl)piperazine-1-carboxylate

: 1616595-97-1
(9aS)-tert-butyl 3-(3-nitrophenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate

Guidance literature:: (S)-tert-butyl 3-(hydroxymethyl)-4-(2-(3-nitrophenyl)-2-oxoethyl)piperazine-1-carboxylate; With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃;

di-tert-butyl dicarbonate; With sodium hydrogencarbonate; In dichloromethane; water; for 2h;

Reference yield:

: 1443739-27-2
(S)-tert-butyl 3-(hydroxymethyl)-4-(2-(3-nitrophenyl)-2-oxoethyl)piperazine-1-carboxylate

: 1443737-33-4
tert-butyl (3R,9aS)-3-[3-(1H-tetrazol-1-yl)phenyl]hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylsilane; trifluoroacetic acid / dichloromethane / 20 °C

1.2: 2 h

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate

3.1: acetic acid; sodium azide / 3 h / Reflux

With triethylsilane; sodium azide; palladium 10% on activated carbon; hydrogen; acetic acid; trifluoroacetic acid; In dichloromethane; ethyl acetate;