tert-butyl endo-3-(4-(2-fluoro-4-(methylsulfonyl)phenylamino)-6,7-dimethoxyquinazolin-2-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:tert-butyl endo-3-(4-(2-fluoro-4-(methylsulfonyl)phenylamino)-6,7-dimethoxyquinazolin-2-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:1424337-00-7
Molecular Formula:C₂₉H₃₆FN₅O₆S
Molecular Weight:601.699
Hs Code.:

Synonyms:tert-butyl endo-3-(4-(2-fluoro-4-(methylsulfonyl)phenylamino)-6,7-dimethoxyquinazolin-2-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Chemical Property of tert-butyl endo-3-(4-(2-fluoro-4-(methylsulfonyl)phenylamino)-6,7-dimethoxyquinazolin-2-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Technology Process of tert-butyl endo-3-(4-(2-fluoro-4-(methylsulfonyl)phenylamino)-6,7-dimethoxyquinazolin-2-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 3 articles about tert-butyl endo-3-(4-(2-fluoro-4-(methylsulfonyl)phenylamino)-6,7-dimethoxyquinazolin-2-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 207405-68-3,174486-93-2
tert-butyl 3-endo-amino-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1424336-77-5
2-chloro-4-(2-fluoro-4-methylsulfonylphenylamino)-6,7-dimethoxyquinazoline

: 1424337-00-7
tert-butyl endo-3-(4-(2-fluoro-4-(methylsulfonyl)phenylamino)-6,7-dimethoxyquinazolin-2-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; for 24h; Reflux;
DOI:10.1016/j.bmc.2012.12.013

Reference yield:

: 27631-29-4
2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

: 1424337-00-7
tert-butyl endo-3-(4-(2-fluoro-4-(methylsulfonyl)phenylamino)-6,7-dimethoxyquinazolin-2-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 24 h / Reflux

With sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; butan-1-ol;
DOI:10.1016/j.bmc.2012.12.013

Reference yield:

: 832755-13-2
2-fluoro-4-methanesulfonylaniline

: 1424337-00-7
tert-butyl endo-3-(4-(2-fluoro-4-(methylsulfonyl)phenylamino)-6,7-dimethoxyquinazolin-2-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 24 h / Reflux

With sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; butan-1-ol;
DOI:10.1016/j.bmc.2012.12.013