1,1-dimethylethyl (7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzo diazepin-3-yl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl (7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzo diazepin-3-yl)carbamate
CAS No.:1300089-86-4
Molecular Formula:C₂₀H₂₀IN₃O₃
Molecular Weight:477.302
Hs Code.:

Synonyms:1,1-dimethylethyl (7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzo diazepin-3-yl)carbamate

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Chemical Property of 1,1-dimethylethyl (7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzo diazepin-3-yl)carbamate

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Technology Process of 1,1-dimethylethyl (7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzo diazepin-3-yl)carbamate

There total 5 articles about 1,1-dimethylethyl (7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzo diazepin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1300089-87-5
3-amino-7-iodo-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

: 1300089-86-4
1,1-dimethylethyl (7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzo diazepin-3-yl)carbamate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 2835-77-0
(2-aminophenyl)(phenyl)methanone

: 1300089-86-4
1,1-dimethylethyl (7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzo diazepin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Iodine monochloride / dichloromethane / -70 - 20 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / tetrahydrofuran / 3 h / 0 °C

2.2: 0 - 20 °C

2.3: 1 h / 0 °C

3.1: ammonium acetate; acetic acid / 3 h / 20 °C

4.1: hydrogen bromide; acetic acid / 1 h / 80 °C

5.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

With oxalyl dichloride; ammonium acetate; hydrogen bromide; Iodine monochloride; acetic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 51073-69-9
(2-amino-5-iodophenyl)(phenyl)methanone

: 1300089-86-4
1,1-dimethylethyl (7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzo diazepin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / tetrahydrofuran / 3 h / 0 °C

1.2: 0 - 20 °C

1.3: 1 h / 0 °C

2.1: ammonium acetate; acetic acid / 3 h / 20 °C

3.1: hydrogen bromide; acetic acid / 1 h / 80 °C

4.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

With oxalyl dichloride; ammonium acetate; hydrogen bromide; acetic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran;