C₃₄H₄₃N₅O₄

Base Information

• Chemical Name: C₃₄H₄₃N₅O₄
• CAS No.: 1542166-86-8
• Molecular Formula: C₃₄H₄₃N₅O₄
• Molecular Weight: 585.747
• Mol file: 1542166-86-8.mol

Synonyms:C₃₄H₄₃N₅O₄

Chemical Property of C₃₄H₄₃N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₄H₄₃N₅O₄

There total 6 articles about C₃₄H₄₃N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(S)-tert-butyl 4-((((S)-1-amino-1-(hydroxyimino)-4-oxo-4-(tritylamino)butan-2-yl)amino)methyl)-2,2-dimethyloxazolidine-3-carboxylate (1542166-92-6) → C34H43N5O4 (1542166-86-8)

Guidance literature:

(S)-tert-butyl 4-((((S)-1-amino-1-(hydroxyimino)-4-oxo-4-(tritylamino)butan-2-yl)amino)methyl)-2,2-dimethyloxazolidine-3-carboxylate; With acetic acid; In methanol; water; at 25 ℃;

With sodium hydroxide; In dichloromethane; water;

DOI:10.1021/ja412298c

Reference yield:

(R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine (95715-87-0) → C34H43N5O4 (1542166-86-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium tris(acetoxy)borohydride / dichloromethane / 12.25 h / 25 °C / Molecular sieve; Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 0 - 25 °C / Inert atmosphere

2.2: 0.5 h / 0 - 25 °C

3.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; ethyl acetate / 2 h / 0 - 50 °C

4.1: hydroxylamine / water; ethanol / 12 h / 25 °C

5.1: acetic acid / water; methanol / 25 °C

With hydroxylamine; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate;

DOI:10.1021/ja412298c

Reference yield:

(S)-2-((((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-4-oxo-4-(tritylamino)butanoic acid (1542166-89-1) → C34H43N5O4 (1542166-86-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 0 - 25 °C / Inert atmosphere

1.2: 0.5 h / 0 - 25 °C

2.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; ethyl acetate / 2 h / 0 - 50 °C

3.1: hydroxylamine / water; ethanol / 12 h / 25 °C

4.1: acetic acid / water; methanol / 25 °C

With hydroxylamine; benzotriazol-1-ol; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate;

DOI:10.1021/ja412298c

upstream raw materials:

(S)-2-((((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-4-oxo-4-(tritylamino)butanoic acid

(R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine

(S)-2-Amino-N-trityl-succinamic acid

(S)-tert-butyl 4-((((S)-1-amino-1,4-dioxo-4-(tritylamino)butan-2-yl)amino)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Downstream raw materials:

tert-butyl 2-((5S,8S)-6-(tert-butyloxycarbonyl)-8-(hydroxymethyl)-12,12-dimethyl-3,10-dioxo-1,1,1-triphenyl-11-oxa-2,6,9-triazatridecan-5-yl)-6-((tert-butyloxycarbonyl)amino)-5-methylpyrimidine-4-carboxylate

(S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)-5-methylpyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)amino)propanoic acid

4-tert-butyl 6-ethyl 2-((S)-1-((((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate

4-(tert-butyl) 6-ethyl 2-((S)-1-((((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)pyrimidine-4,6-dicarboxylate