(4S,5S)-(-)-4-benzyl-5-(2,2-dimethyl-1,3-dioxan-4-ylmethyl)-3-N-(4-methoxybenzyl)-2-oxazolidinone

Base Information

Chemical Name:(4S,5S)-(-)-4-benzyl-5-(2,2-dimethyl-1,3-dioxan-4-ylmethyl)-3-N-(4-methoxybenzyl)-2-oxazolidinone
CAS No.:272772-52-8
Molecular Formula:C₂₅H₃₁NO₅
Molecular Weight:425.525
Hs Code.:

Synonyms:(4S,5S)-(-)-4-benzyl-5-(2,2-dimethyl-1,3-dioxan-4-ylmethyl)-3-N-(4-methoxybenzyl)-2-oxazolidinone

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Chemical Property of (4S,5S)-(-)-4-benzyl-5-(2,2-dimethyl-1,3-dioxan-4-ylmethyl)-3-N-(4-methoxybenzyl)-2-oxazolidinone

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Technology Process of (4S,5S)-(-)-4-benzyl-5-(2,2-dimethyl-1,3-dioxan-4-ylmethyl)-3-N-(4-methoxybenzyl)-2-oxazolidinone

There total 5 articles about (4S,5S)-(-)-4-benzyl-5-(2,2-dimethyl-1,3-dioxan-4-ylmethyl)-3-N-(4-methoxybenzyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 77-76-9
2,2-dimethoxy-propane

: 272772-50-6
(4S,5S)-(-)-4-benzyl-5-(2,4-dihydroxybutyl)-3-(N-4-methoxybenzyl)-2-oxazolidinone

: 272772-52-8
(4S,5S)-(-)-4-benzyl-5-(2,2-dimethyl-1,3-dioxan-4-ylmethyl)-3-N-(4-methoxybenzyl)-2-oxazolidinone

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 96h; Heating;

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 272772-52-8
(4S,5S)-(-)-4-benzyl-5-(2,2-dimethyl-1,3-dioxan-4-ylmethyl)-3-N-(4-methoxybenzyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / tetrahydrofuran / 24 h / 20 °C

2: 87 percent / NaH in mineral oil / dimethylformamide / 1.5 h / 0 °C

3: 91 percent / 97 percent concd. sulfuric acid; silica gel / CH₂Cl₂ / 2 h / 0 °C

4: 94 percent / LiBH₄; EtOH / tetrahydrofuran / 24 h / 20 °C

5: 80 percent / p-toluenesulfonic acid monohydrate / benzene / 96 h / Heating

With lithium borohydride; ethanol; sulfuric acid; silica gel; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene; 1: Alkylation / 2: Alkylation / 3: Cyclization / 4: Reduction / 5: cyclocondensation;

Reference yield:

: 199926-80-2
ethyl (S)-(-)-6-(N-tert-butoxycarbonyl)amino-3-ethoxy-7-phenylhepta-2,4-dienoate

: 272772-52-8
(4S,5S)-(-)-4-benzyl-5-(2,2-dimethyl-1,3-dioxan-4-ylmethyl)-3-N-(4-methoxybenzyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / NaH in mineral oil / dimethylformamide / 1.5 h / 0 °C

2: 91 percent / 97 percent concd. sulfuric acid; silica gel / CH₂Cl₂ / 2 h / 0 °C

3: 94 percent / LiBH₄; EtOH / tetrahydrofuran / 24 h / 20 °C

4: 80 percent / p-toluenesulfonic acid monohydrate / benzene / 96 h / Heating

With lithium borohydride; ethanol; sulfuric acid; silica gel; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene; 1: Alkylation / 2: Cyclization / 3: Reduction / 4: cyclocondensation;