2-[(2-Methylpropyl)amino]-1-phenylethan-1-ol

Base Information

• Chemical Name: 2-[(2-Methylpropyl)amino]-1-phenylethan-1-ol
• CAS No.: 55474-91-4
• Molecular Formula: C₁₂H₁₉NO
• Molecular Weight: 193.289
• DSSTox Substance ID: DTXSID901239940
• Mol file: 55474-91-4.mol

Synonyms:2-[(2-methylpropyl)amino]-1-phenylethan-1-ol;55474-91-4;2-(2-methylpropylamino)-1-phenylethanol;SCHEMBL7114926;UERFLMOOWGTPDV-UHFFFAOYSA-N;2-(isobutylamino)-1-phenylethanol;DTXSID901239940;AKOS002629415;AKOS017262194;CS-0261758;EN300-79859;alpha-[[(2-Methylpropyl)amino]methyl]benzenemethanol;Z31378498

Chemical Property of 2-[(2-Methylpropyl)amino]-1-phenylethan-1-ol

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 193.146664230
• Heavy Atom Count: 14
• Complexity: 141

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)CNCC(C1=CC=CC=C1)O

Technology Process of 2-[(2-Methylpropyl)amino]-1-phenylethan-1-ol

There total 5 articles about 2-[(2-Methylpropyl)amino]-1-phenylethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-t-butyloxycarbonyl-N-isobutyl-2-hydroxy-2-phenylethylamine → 2-(isobutylamino)-1-phenylethanol (55474-91-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 22 ℃; for 2h;

DOI:10.1016/S0040-4039(00)73113-3

Reference yield:

2-isopropyl-5-phenyl-1,3-oxazolidine (1378849-89-8) → 2-(isobutylamino)-1-phenylethanol (55474-91-4)

Guidance literature:

With sodium tetrahydroborate;

Reference yield:

benzaldehyde (100-52-7) → 2-(isobutylamino)-1-phenylethanol (55474-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / 1.) s-BuLi, TMEDA / 1.) THF, -78 deg C, 8 h; 2.) -78 deg C, 1 h

2: 73 percent / 15percent TFA / CH₂Cl₂ / 2 h / 22 °C

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)73113-3

upstream raw materials:

Isobutyl iodide

benzaldehyde

2-isopropyl-5-phenyl-1,3-oxazolidine

Downstream raw materials:

C₁₉H₂₅NO₃S

N-(2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]oxy}-2-phenylethyl)-2-methylpropan-1-amine

2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl](isobutyl)amino}-1-phenylethanol