4-Nitro-benzoic acid 1-methyl-1-(3-methyl-bicyclo[1.1.1]pent-1-yl)-ethyl ester

Base Information

Chemical Name:4-Nitro-benzoic acid 1-methyl-1-(3-methyl-bicyclo[1.1.1]pent-1-yl)-ethyl ester
CAS No.:83249-20-1
Molecular Formula:C₁₆H₁₉NO₄
Molecular Weight:289.331
Hs Code.:

Synonyms:4-Nitro-benzoic acid 1-methyl-1-(3-methyl-bicyclo[1.1.1]pent-1-yl)-ethyl ester

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Chemical Property of 4-Nitro-benzoic acid 1-methyl-1-(3-methyl-bicyclo[1.1.1]pent-1-yl)-ethyl ester

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Technology Process of 4-Nitro-benzoic acid 1-methyl-1-(3-methyl-bicyclo[1.1.1]pent-1-yl)-ethyl ester

There total 5 articles about 4-Nitro-benzoic acid 1-methyl-1-(3-methyl-bicyclo[1.1.1]pent-1-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 83249-17-6
3-methyl-1-(2-hydroxy-2-propyl)bicyclo<1.1.1>pentane

: 122-04-3
4-nitro-benzoyl chloride

: 83249-20-1
4-Nitro-benzoic acid 1-methyl-1-(3-methyl-bicyclo[1.1.1]pent-1-yl)-ethyl ester

Guidance literature:: With dmap; In pyridine; at 43 ℃; for 46h;
DOI:10.1021/jo00146a031

Reference yield:

: 65862-01-3
3-methylbicyclo<1.1.1>pentane-1-carboxylic acid

: 83249-20-1
4-Nitro-benzoic acid 1-methyl-1-(3-methyl-bicyclo[1.1.1]pent-1-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / diethyl ether / 4 h / Ambient temperature

2: 69 percent / diethyl ether / 1.) 0 deg C, 2 h, 2.) room temperature, 22 h

3: 69 percent / 4-(dimethylamino)pyridine / pyridine / 46 h / 43 °C

With dmap; In pyridine; diethyl ether;
DOI:10.1021/jo00146a031

Reference yield:

: 30494-14-5
methyl 3-methyl-2,2-dichlorobicyclo<1.1.1>pentane-1-carboxylate

: 83249-20-1
4-Nitro-benzoic acid 1-methyl-1-(3-methyl-bicyclo[1.1.1]pent-1-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) tri-n-butyltin hydride, azobis(isobutyronitrile), 2.) NaOH / 1.) 130 deg C, 108 h, 2.) H₂O, reflux, 2 h

2: 51 percent / diethyl ether / 4 h / Ambient temperature

3: 69 percent / diethyl ether / 1.) 0 deg C, 2 h, 2.) room temperature, 22 h

4: 69 percent / 4-(dimethylamino)pyridine / pyridine / 46 h / 43 °C

With dmap; sodium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In pyridine; diethyl ether;
DOI:10.1021/jo00146a031