[2,4-bis(benzyloxy)-5-isopropenylphenyl]-[5-(methanesulfonyloxymethyl)-1,3-dihydroisoindol-2-yl]methanone

Base Information

• Chemical Name: [2,4-bis(benzyloxy)-5-isopropenylphenyl]-[5-(methanesulfonyloxymethyl)-1,3-dihydroisoindol-2-yl]methanone
• CAS No.: 1619266-92-0
• Molecular Formula: C₃₄H₃₃NO₆S
• Molecular Weight: 583.705
• Mol file: 1619266-92-0.mol

Synonyms:[2,4-bis(benzyloxy)-5-isopropenylphenyl]-[5-(methanesulfonyloxymethyl)-1,3-dihydroisoindol-2-yl]methanone

Chemical Property of [2,4-bis(benzyloxy)-5-isopropenylphenyl]-[5-(methanesulfonyloxymethyl)-1,3-dihydroisoindol-2-yl]methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2,4-bis(benzyloxy)-5-isopropenylphenyl]-[5-(methanesulfonyloxymethyl)-1,3-dihydroisoindol-2-yl]methanone

There total 4 articles about [2,4-bis(benzyloxy)-5-isopropenylphenyl]-[5-(methanesulfonyloxymethyl)-1,3-dihydroisoindol-2-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

[2,4-is(benzyloxy)-5-isopropenylphenyl]-[5-(hydroxymethyl)-1,3-dihydroisoindol-2-yl]methanone (1351815-44-5) + methanesulfonyl chloride (124-63-0) → [2,4-bis(benzyloxy)-5-isopropenylphenyl]-[5-(methanesulfonyloxymethyl)-1,3-dihydroisoindol-2-yl]methanone (1619266-92-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12.5h; Inert atmosphere;

DOI:10.1080/00397911.2014.902068

Reference yield:

2,4-bis(benzyloxy)-5-isopropenyl-N-propargylbenzamide (1619266-91-9) → [2,4-bis(benzyloxy)-5-isopropenylphenyl]-[5-(methanesulfonyloxymethyl)-1,3-dihydroisoindol-2-yl]methanone (1619266-92-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: tris(triphenylphosphine)rhodium(l) chloride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 12.5 h / 0 - 20 °C / Inert atmosphere

With tris(triphenylphosphine)rhodium(l) chloride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1080/00397911.2014.902068

Reference yield:

2,4-Bis(benzyloxy)-5-isopropenyl-N,N-dipropargylbenzamide (1019890-32-4) → [2,4-bis(benzyloxy)-5-isopropenylphenyl]-[5-(methanesulfonyloxymethyl)-1,3-dihydroisoindol-2-yl]methanone (1619266-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tris(triphenylphosphine)rhodium(l) chloride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 12.5 h / 0 - 20 °C / Inert atmosphere

With tris(triphenylphosphine)rhodium(l) chloride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1080/00397911.2014.902068

upstream raw materials:

2,4-bis(benzyloxy)-5-isopropenyl-N-propargylbenzamide

2,4-Bis(benzyloxy)-5-isopropenyl-N,N-dipropargylbenzamide

[2,4-is(benzyloxy)-5-isopropenylphenyl]-[5-(hydroxymethyl)-1,3-dihydroisoindol-2-yl]methanone

methanesulfonyl chloride

Downstream raw materials:

2-(2,4-bis-benzyloxy-5-isopropenylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone