tert-butyl (4-{[3-(2,3-bis(benzyloxy)benzoylamino)propyl]-tert-butoxycarbonylamino}butyl)carbamate

Base Information

Chemical Name:tert-butyl (4-{[3-(2,3-bis(benzyloxy)benzoylamino)propyl]-tert-butoxycarbonylamino}butyl)carbamate
CAS No.:705281-84-1
Molecular Formula:C₃₈H₅₁N₃O₇
Molecular Weight:661.839
Hs Code.:

Synonyms:tert-butyl (4-{[3-(2,3-bis(benzyloxy)benzoylamino)propyl]-tert-butoxycarbonylamino}butyl)carbamate

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Chemical Property of tert-butyl (4-{[3-(2,3-bis(benzyloxy)benzoylamino)propyl]-tert-butoxycarbonylamino}butyl)carbamate

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Technology Process of tert-butyl (4-{[3-(2,3-bis(benzyloxy)benzoylamino)propyl]-tert-butoxycarbonylamino}butyl)carbamate

There total 8 articles about tert-butyl (4-{[3-(2,3-bis(benzyloxy)benzoylamino)propyl]-tert-butoxycarbonylamino}butyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 68076-39-1
N₁,N₅-di-boc-spermidine

: 69146-58-3
2,3-bis(benzyloxy)benzoyl chloride

: 705281-84-1
tert-butyl (4-{[3-(2,3-bis(benzyloxy)benzoylamino)propyl]-tert-butoxycarbonylamino}butyl)carbamate

Guidance literature:: With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 2h;
DOI:10.1021/jo049803l

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 705281-84-1
tert-butyl (4-{[3-(2,3-bis(benzyloxy)benzoylamino)propyl]-tert-butoxycarbonylamino}butyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / triethylamine / methanol / 20 °C

2: 70 percent / potassium carbonate / acetonitrile / 24 h / 50 °C

3: 91 percent / triethylamine / methanol

4: 91 percent / hydrogen; NH₃; Raney nickel / ethanol; H₂O / 24 h / 2585.74 Torr

5: 86 percent / NaOH / CH₂Cl₂; H₂O / 2 h / 20 °C

With sodium hydroxide; ammonia; hydrogen; nickel; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo049803l

Reference yield:

: 68076-36-8
1-amino-4-[(tert-butyloxycarbonyl)amino]butane

: 705281-84-1
tert-butyl (4-{[3-(2,3-bis(benzyloxy)benzoylamino)propyl]-tert-butoxycarbonylamino}butyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / potassium carbonate / acetonitrile / 24 h / 50 °C

2: 91 percent / triethylamine / methanol

3: 91 percent / hydrogen; NH₃; Raney nickel / ethanol; H₂O / 24 h / 2585.74 Torr

4: 86 percent / NaOH / CH₂Cl₂; H₂O / 2 h / 20 °C

With sodium hydroxide; ammonia; hydrogen; nickel; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo049803l