Methyl 6-[(3-{[(benzyloxy)carbonyl](methyl)amino}propyl)(methyl)carbam oyl]pyridine-3-carboxylate

Base Information

Chemical Name:Methyl 6-[(3-{[(benzyloxy)carbonyl](methyl)amino}propyl)(methyl)carbam oyl]pyridine-3-carboxylate
CAS No.:1246246-76-3
Molecular Formula:C₂₁H₂₅N₃O₅
Molecular Weight:399.447
Hs Code.:

Synonyms:Methyl 6-[(3-{[(benzyloxy)carbonyl](methyl)amino}propyl)(methyl)carbam oyl]pyridine-3-carboxylate

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Chemical Property of Methyl 6-[(3-{[(benzyloxy)carbonyl](methyl)amino}propyl)(methyl)carbam oyl]pyridine-3-carboxylate

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Technology Process of Methyl 6-[(3-{[(benzyloxy)carbonyl](methyl)amino}propyl)(methyl)carbam oyl]pyridine-3-carboxylate

There total 1 articles about Methyl 6-[(3-{[(benzyloxy)carbonyl](methyl)amino}propyl)(methyl)carbam oyl]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 17874-79-2
pyridine-2,5-dicarboxylic acid 5-methyl ester

: 501-53-1,94274-21-2
benzyl chloroformate

: 111-33-1
1,3-bis(methylamino)propane

: 1246246-76-3
Methyl 6-[(3-{[(benzyloxy)carbonyl](methyl)amino}propyl)(methyl)carbam oyl]pyridine-3-carboxylate

Guidance literature:: pyridine-2,5-dicarboxylic acid 5-methyl ester; With pivaloyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 0.25h; Cooling with ice;

1,3-bis(methylamino)propane; In dichloromethane; at 20 ℃; Cooling with ice;

benzyl chloroformate; With triethylamine; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

: 1246246-76-3
Methyl 6-[(3-{[(benzyloxy)carbonyl](methyl)amino}propyl)(methyl)carbam oyl]pyridine-3-carboxylate

: N-{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-5-(hydroxymethyl)-N-methylpyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / methanol / 10 h / 50 °C

1.2: pH 3

2.1: borane-THF / tetrahydrofuran / 0.75 h / 20 °C / Cooling with ice

2.2: 1 h / 20 °C / Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 20 °C

3.2: 1.25 h / 20 °C / Cooling with ice

With borane-THF; water; hydrogen; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield:

: 1246246-76-3
Methyl 6-[(3-{[(benzyloxy)carbonyl](methyl)amino}propyl)(methyl)carbam oyl]pyridine-3-carboxylate

: 1246246-78-5
Benzyl {3-[{[5-(hydroxymethyl)pyridin-2-yl]carbonyl}(methyl)amino]propyl}methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / methanol / 10 h / 50 °C

1.2: pH 3

2.1: borane-THF / tetrahydrofuran / 0.75 h / 20 °C / Cooling with ice

2.2: 1 h / 20 °C / Cooling with ice

With borane-THF; water; sodium hydroxide; In tetrahydrofuran; methanol;