(E)-2-(2-phenylethynyl)-5-(thiophen-2-yl)-N-tosylpent-2-en-4-ynamide

Base Information

• Chemical Name: (E)-2-(2-phenylethynyl)-5-(thiophen-2-yl)-N-tosylpent-2-en-4-ynamide
• CAS No.: 1575710-21-2
• Molecular Formula: C₂₄H₁₇NO₃S₂
• Molecular Weight: 431.536
• Mol file: 1575710-21-2.mol

Synonyms:(E)-2-(2-phenylethynyl)-5-(thiophen-2-yl)-N-tosylpent-2-en-4-ynamide

Chemical Property of (E)-2-(2-phenylethynyl)-5-(thiophen-2-yl)-N-tosylpent-2-en-4-ynamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (E)-2-(2-phenylethynyl)-5-(thiophen-2-yl)-N-tosylpent-2-en-4-ynamide

There total 1 articles about (E)-2-(2-phenylethynyl)-5-(thiophen-2-yl)-N-tosylpent-2-en-4-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-toluenesulfonyl azide (941-55-9) + thiophen-2-yl-propynal (13781-33-4) + buta-1,3-diynylbenzene (5701-81-5) → (E)-2-(2-phenylethynyl)-5-(thiophen-2-yl)-N-tosylpent-2-en-4-ynamide (1575710-21-2)

Guidance literature:

With copper(l) iodide; tetraethylammonium iodide; lithium hydroxide; In tetrahydrofuran; tert-butyl alcohol; at 10 ℃; for 5h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol500574b

Reference yield: 77.0%

(E)-2-(2-phenylethynyl)-5-(thiophen-2-yl)-N-tosylpent-2-en-4-ynamide (1575710-21-2) + allyl bromide (106-95-6) → 3,5-diallyl-2-phenyl-6-(thiophen-2-yl)furo[2,3-b]pyridine (1575710-67-6)

Guidance literature:

With palladium dichloride; In N,N-dimethyl-formamide; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol500574b

Reference yield: 76.0%

hex-3-yne (928-49-4) + (E)-2-(2-phenylethynyl)-5-(thiophen-2-yl)-N-tosylpent-2-en-4-ynamide (1575710-21-2) → 4,5-diethyl-3-hydroxy-3-phenyl-6-(thiophene-2-carbonyl)-2-tosylisoindolin-1-one (1621074-08-5)

Guidance literature:

With oxygen; copper(ll) bromide; palladium dichloride; In N,N-dimethyl-formamide; at 35 ℃; for 3h; under 760.051 Torr;

DOI:10.1021/ja506795u

upstream raw materials:

4-toluenesulfonyl azide

thiophen-2-yl-propynal

buta-1,3-diynylbenzene

Downstream raw materials:

3,5-diallyl-2-phenyl-6-(thiophen-2-yl)furo[2,3-b]pyridine

2-phenyl-6-(thiophen-2-yl)furo[2,3-b]pyridine

(E)-2-(phenylethynyl)-5-(thiophen-2-yl)pent-2-en-4-ynoic acid

4,5-diethyl-3-hydroxy-3-phenyl-6-(thiophene-2-carbonyl)-2-tosylisoindolin-1-one