6-[8-(benzothiazol-2-yl-hydrazono)-5,6,7,8-tetrahydro-naphthalen-2-yl]-3-(3-phenoxypropoxy)-pyridine-2-carboxylic acid

Base Information

Chemical Name:6-[8-(benzothiazol-2-yl-hydrazono)-5,6,7,8-tetrahydro-naphthalen-2-yl]-3-(3-phenoxypropoxy)-pyridine-2-carboxylic acid
CAS No.:1135871-35-0
Molecular Formula:C₃₂H₂₈N₄O₄S
Molecular Weight:564.665
Hs Code.:

Synonyms:6-[8-(benzothiazol-2-yl-hydrazono)-5,6,7,8-tetrahydro-naphthalen-2-yl]-3-(3-phenoxypropoxy)-pyridine-2-carboxylic acid

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Chemical Property of 6-[8-(benzothiazol-2-yl-hydrazono)-5,6,7,8-tetrahydro-naphthalen-2-yl]-3-(3-phenoxypropoxy)-pyridine-2-carboxylic acid

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Technology Process of 6-[8-(benzothiazol-2-yl-hydrazono)-5,6,7,8-tetrahydro-naphthalen-2-yl]-3-(3-phenoxypropoxy)-pyridine-2-carboxylic acid

There total 5 articles about 6-[8-(benzothiazol-2-yl-hydrazono)-5,6,7,8-tetrahydro-naphthalen-2-yl]-3-(3-phenoxypropoxy)-pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: C₂₅H₂₃NO₅

: 615-21-4
1,3-benzothiazol-2-ylhydrazine

: 1135871-35-0
6-[8-(benzothiazol-2-yl-hydrazono)-5,6,7,8-tetrahydro-naphthalen-2-yl]-3-(3-phenoxypropoxy)-pyridine-2-carboxylic acid

Guidance literature:: With acetic acid; at 60 ℃; for 16h;

Reference yield:

: 321601-48-3
methyl 6-bromo-3-hydroxypyridine-2-carboxylate

: 1135871-35-0
6-[8-(benzothiazol-2-yl-hydrazono)-5,6,7,8-tetrahydro-naphthalen-2-yl]-3-(3-phenoxypropoxy)-pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / ISOPROPYLAMIDE / 3 h / 90 °C

2: tetrabutylammomium bromide; potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 1.5 h / 100 °C / Microwave irradiation

3: acetic acid / 16 h / 60 °C

With tetrabutylammomium bromide; sodium hydride; potassium carbonate; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; ISOPROPYLAMIDE; water; 2: Suzuki Coupling;

Reference yield:

: 32281-97-3
7-bromo-3,4-dihydro-2H-naphthalen-1-one

: 1135871-35-0
6-[8-(benzothiazol-2-yl-hydrazono)-5,6,7,8-tetrahydro-naphthalen-2-yl]-3-(3-phenoxypropoxy)-pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 14 h / 60 °C

2: tetrabutylammomium bromide; potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 1.5 h / 100 °C / Microwave irradiation

3: acetic acid / 16 h / 60 °C

With tetrabutylammomium bromide; potassium acetate; potassium carbonate; acetic acid; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; water; 2: Suzuki Coupling;