methyl (2S)-2-[[(2S)-2-amino-3-cyclohexyl-propanoyl]amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propanoate

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Chemical Name:methyl (2S)-2-[[(2S)-2-amino-3-cyclohexyl-propanoyl]amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propanoate
CAS No.:1027038-43-2
Molecular Formula:C₁₇H₂₉N₃O₄
Molecular Weight:339.435
Hs Code.:

Synonyms:methyl (2S)-2-[[(2S)-2-amino-3-cyclohexyl-propanoyl]amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propanoate

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Chemical Property of methyl (2S)-2-[[(2S)-2-amino-3-cyclohexyl-propanoyl]amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propanoate

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Technology Process of methyl (2S)-2-[[(2S)-2-amino-3-cyclohexyl-propanoyl]amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propanoate

There total 8 articles about methyl (2S)-2-[[(2S)-2-amino-3-cyclohexyl-propanoyl]amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 898264-60-3
2-(2-tert-butoxycarbonylamino-3-cyclohexyl-propionylamino)-3-(2-oxo-pyrrolidin-3-yl)-propionic acid methyl ester

: 1027038-43-2
methyl (2S)-2-[[(2S)-2-amino-3-cyclohexyl-propanoyl]amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propanoate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h;
DOI:10.1021/jm0603926

Reference yield:

: 6525-53-7,16422-27-8,40149-68-6
L-glutamic acid dimethyl ester

: 1027038-43-2
methyl (2S)-2-[[(2S)-2-amino-3-cyclohexyl-propanoyl]amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 88.0 g / Et₃N / methanol / 20 °C

2.1: LiHMDS / tetrahydrofuran / 1.5 h / -78 °C

2.2: 83 percent / tetrahydrofuran / -78 °C

3.1: H₂ / Pd/C / 2 h / 3620.04 Torr

4.1: 5.55 g / Et₃N / tetrahydrofuran / 60 °C

5.1: HCl / dioxane / 0.5 h / 20 °C

6.1: 0.576 g / EDC; HOBt / CH₂Cl₂ / 2 h / 20 °C

7.1: HCl / dioxane / 0.5 h / 20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm0603926

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 1027038-43-2
methyl (2S)-2-[[(2S)-2-amino-3-cyclohexyl-propanoyl]amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: TMSCl / 15 h / 20 °C

2.1: 88.0 g / Et₃N / methanol / 20 °C

3.1: LiHMDS / tetrahydrofuran / 1.5 h / -78 °C

3.2: 83 percent / tetrahydrofuran / -78 °C

4.1: H₂ / Pd/C / 2 h / 3620.04 Torr

5.1: 5.55 g / Et₃N / tetrahydrofuran / 60 °C

6.1: HCl / dioxane / 0.5 h / 20 °C

7.1: 0.576 g / EDC; HOBt / CH₂Cl₂ / 2 h / 20 °C

8.1: HCl / dioxane / 0.5 h / 20 °C

With hydrogenchloride; chloro-trimethyl-silane; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm0603926